4-iso-butyl-6-(2-iso-propoxyphenyl)-N'-(2-phenylacetyl)pyridazine-3-carbohydrazide

Base Information

Chemical Name:4-iso-butyl-6-(2-iso-propoxyphenyl)-N'-(2-phenylacetyl)pyridazine-3-carbohydrazide
CAS No.:952591-48-9
Molecular Formula:C₂₆H₃₀N₄O₃
Molecular Weight:446.549
Hs Code.:

Synonyms:4-iso-butyl-6-(2-iso-propoxyphenyl)-N'-(2-phenylacetyl)pyridazine-3-carbohydrazide

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Chemical Property of 4-iso-butyl-6-(2-iso-propoxyphenyl)-N'-(2-phenylacetyl)pyridazine-3-carbohydrazide

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Technology Process of 4-iso-butyl-6-(2-iso-propoxyphenyl)-N'-(2-phenylacetyl)pyridazine-3-carbohydrazide

There total 5 articles about 4-iso-butyl-6-(2-iso-propoxyphenyl)-N'-(2-phenylacetyl)pyridazine-3-carbohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 952591-27-4
ethyl 6-chloro-4-iso-butylpyridazine-3-carboxylate

: 952591-48-9
4-iso-butyl-6-(2-iso-propoxyphenyl)-N'-(2-phenylacetyl)pyridazine-3-carbohydrazide

Guidance literature:: Multi-step reaction with 3 steps

1.1: Pd(PPh₃)4 / 1,2-dimethoxy-ethane / 0.25 h

1.2: NaHCO₃ / H₂O; ethanol / 2 h / Heating

2.1: lithium hydroxide hydrate / tetrahydrofuran; H₂O / 0 °C

3.1: EDCI; HOBt; DIPEA / CH₂Cl₂ / 20 °C

With lithium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; 1.2: Suzuki coupling;
DOI:10.1021/ol701487g

Reference yield:

: 75680-92-1
6-chloro-3-pyridazinecarboxylic acid ethyl ester

: 952591-48-9
4-iso-butyl-6-(2-iso-propoxyphenyl)-N'-(2-phenylacetyl)pyridazine-3-carbohydrazide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 0.564 g / H₂SO₄; AgNO₃; (NH₄)2S₂O₈ / H₂O / 65 - 75 °C

2.1: Pd(PPh₃)4 / 1,2-dimethoxy-ethane / 0.25 h

2.2: NaHCO₃ / H₂O; ethanol / 2 h / Heating

3.1: lithium hydroxide hydrate / tetrahydrofuran; H₂O / 0 °C

4.1: EDCI; HOBt; DIPEA / CH₂Cl₂ / 20 °C

With lithium hydroxide; ammonium peroxydisulfate; sulfuric acid; benzotriazol-1-ol; silver nitrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; 2.2: Suzuki coupling;
DOI:10.1021/ol701487g

Reference yield:

: C₁₈H₂₂O₃N₂

: 937-39-3
2-phenylacetylhydrazine

: 952591-48-9
4-iso-butyl-6-(2-iso-propoxyphenyl)-N'-(2-phenylacetyl)pyridazine-3-carbohydrazide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;
DOI:10.1021/ol701487g