2-(S)-1-(7-fluoro-2-(3-fluorophenyl)-quinolin-3-yl)ethylcarbamoylbenzoic acid

Base Information

Chemical Name:2-(S)-1-(7-fluoro-2-(3-fluorophenyl)-quinolin-3-yl)ethylcarbamoylbenzoic acid
CAS No.:1464832-46-9
Molecular Formula:C₂₅H₁₈F₂N₂O₃
Molecular Weight:432.426
Hs Code.:

Synonyms:2-(S)-1-(7-fluoro-2-(3-fluorophenyl)-quinolin-3-yl)ethylcarbamoylbenzoic acid

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Chemical Property of 2-(S)-1-(7-fluoro-2-(3-fluorophenyl)-quinolin-3-yl)ethylcarbamoylbenzoic acid

Chemical Property:

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Technology Process of 2-(S)-1-(7-fluoro-2-(3-fluorophenyl)-quinolin-3-yl)ethylcarbamoylbenzoic acid

There total 6 articles about 2-(S)-1-(7-fluoro-2-(3-fluorophenyl)-quinolin-3-yl)ethylcarbamoylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1065481-14-2
(S)-2-(1-(2-chloro-7-fluoroquinolin-3-yl)ethyl)isoindoline-1 ,3-dione

: 768-35-4
3-fluorophenylboronic acid

: 1464832-46-9
2-(S)-1-(7-fluoro-2-(3-fluorophenyl)-quinolin-3-yl)ethylcarbamoylbenzoic acid

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In water; acetonitrile; at 90 ℃; Inert atmosphere;

Reference yield:

: 351-28-0
N-(3-fluorophenyl)acetamide

: 1464832-46-9
2-(S)-1-(7-fluoro-2-(3-fluorophenyl)-quinolin-3-yl)ethylcarbamoylbenzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: trichlorophosphate / 0.5 h / 0 - 20 °C

1.2: 75 °C

2.1: tetrahydrofuran / -20 °C

3.1: manganese(IV) oxide / toluene / 2 h / Reflux

4.1: B-chlorodiisopinocampheylborane / tetrahydrofuran / -45 - 20 °C

5.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; acetonitrile / 90 °C / Inert atmosphere

With manganese(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; di-isopropyl azodicarboxylate; sodium carbonate; triphenylphosphine; B-chlorodiisopinocampheylborane; trichlorophosphate; In tetrahydrofuran; water; toluene; acetonitrile;

Reference yield:

: 1017463-34-1
1-(2-chloro-7-fluoroquinoline-3-yl)ethane-1-ol

: 1464832-46-9
2-(S)-1-(7-fluoro-2-(3-fluorophenyl)-quinolin-3-yl)ethylcarbamoylbenzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: manganese(IV) oxide / toluene / 2 h / Reflux

2: B-chlorodiisopinocampheylborane / tetrahydrofuran / -45 - 20 °C

3: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; acetonitrile / 90 °C / Inert atmosphere

With manganese(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; di-isopropyl azodicarboxylate; sodium carbonate; triphenylphosphine; B-chlorodiisopinocampheylborane; In tetrahydrofuran; water; toluene; acetonitrile;