Technology Process of 6,7-dihydroxy-5-iodo-1-(3',4',5'-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride
There total 12 articles about 6,7-dihydroxy-5-iodo-1-(3',4',5'-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
methanol;
for 0.166667h;
Heating;
DOI:10.1021/jm00081a007
- Guidance literature:
-
Multi-step reaction with 12 steps
1: 73 percent / pyridine, iodine monochloride / dioxane / 144 h / Ambient temperature
2: 85 percent / potassium carbonate / acetone / 6 h / Heating
3: 83 percent / sodium borohydride / tetrahydrofuran / 3 h / 40 °C
4: 77 percent / phosphorus tribromide / CHCl3 / 2 h / 0 °C
5: 73 percent / dimethylformamide / 0.5 h / Ambient temperature
6: 68 percent / 1 M boron tribromide / CH2Cl2 / Ambient temperature
7: 92 percent / potassium carbonate, potassium iodide / acetone / Heating
8: 1 M BH3*THF / tetrahydrofuran / 18 h / Heating
9: toluene / 72 h / Heating
10: phosphorus oxychloride / acetonitrile / 5 h / Heating
11: sodium borohydride / methanol / Ambient temperature
12: 46 percent / concd. HCl / methanol / 0.17 h / Heating
With
pyridine; hydrogenchloride; sodium tetrahydroborate; borane-THF; Iodine monochloride; boron tribromide; phosphorus tribromide; potassium carbonate; potassium iodide; trichlorophosphate;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; chloroform; N,N-dimethyl-formamide; acetone; toluene; acetonitrile;
DOI:10.1021/jm00081a007
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 83 percent / sodium borohydride / tetrahydrofuran / 3 h / 40 °C
2: 77 percent / phosphorus tribromide / CHCl3 / 2 h / 0 °C
3: 73 percent / dimethylformamide / 0.5 h / Ambient temperature
4: 68 percent / 1 M boron tribromide / CH2Cl2 / Ambient temperature
5: 92 percent / potassium carbonate, potassium iodide / acetone / Heating
6: 1 M BH3*THF / tetrahydrofuran / 18 h / Heating
7: toluene / 72 h / Heating
8: phosphorus oxychloride / acetonitrile / 5 h / Heating
9: sodium borohydride / methanol / Ambient temperature
10: 46 percent / concd. HCl / methanol / 0.17 h / Heating
With
hydrogenchloride; sodium tetrahydroborate; borane-THF; boron tribromide; phosphorus tribromide; potassium carbonate; potassium iodide; trichlorophosphate;
In
tetrahydrofuran; methanol; dichloromethane; chloroform; N,N-dimethyl-formamide; acetone; toluene; acetonitrile;
DOI:10.1021/jm00081a007
