(R)-2-chloro-N-(3,3-dimethylbutan-2-yl)-6-((3-fluorobenzyl)oxy)nicotinamide

Base Information

Chemical Name:(R)-2-chloro-N-(3,3-dimethylbutan-2-yl)-6-((3-fluorobenzyl)oxy)nicotinamide
CAS No.:1276013-92-3
Molecular Formula:C₁₉H₂₂ClFN₂O₂
Molecular Weight:364.847
Hs Code.:

Synonyms:(R)-2-chloro-N-(3,3-dimethylbutan-2-yl)-6-((3-fluorobenzyl)oxy)nicotinamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-chloro-N-(3,3-dimethylbutan-2-yl)-6-((3-fluorobenzyl)oxy)nicotinamide

Chemical Property:

Purity/Quality:

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Technology Process of (R)-2-chloro-N-(3,3-dimethylbutan-2-yl)-6-((3-fluorobenzyl)oxy)nicotinamide

There total 4 articles about (R)-2-chloro-N-(3,3-dimethylbutan-2-yl)-6-((3-fluorobenzyl)oxy)nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₃H₉ClFNO₃

: 3850-30-4,22526-47-2,59367-75-8,66228-31-7
(R)-1,2,2-trimethylpropylamine

: 1276013-92-3
(R)-2-chloro-N-(3,3-dimethylbutan-2-yl)-6-((3-fluorobenzyl)oxy)nicotinamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 20h;

Reference yield:

: 38496-18-3
2,6-dichloropyridine-3-carboxylic acid

: 1276013-92-3
(R)-2-chloro-N-(3,3-dimethylbutan-2-yl)-6-((3-fluorobenzyl)oxy)nicotinamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: dmap / tetrahydrofuran

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

2.2: -78 - 20 °C

3.1: water; lithium hydroxide / tetrahydrofuran; methanol / 40 °C

4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 h / 20 °C

With water; sodium hydride; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; dmap; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 1013647-75-0
2,6-dichloropyridine-3-carboxylic acid tert-butyl ester

: 1276013-92-3
(R)-2-chloro-N-(3,3-dimethylbutan-2-yl)-6-((3-fluorobenzyl)oxy)nicotinamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

1.2: -78 - 20 °C

2.1: water; lithium hydroxide / tetrahydrofuran; methanol / 40 °C

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 h / 20 °C

With water; sodium hydride; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;