(2aS,4R,8aS)-8-allyloxycarbonyl-4-[(R)-6-benzyloxyheptyl]-7-methyl-1,2,2a,5,6,7,8,8a-octahydro-5,6,8b-triazaacenaphtylen-8b-ylium

Base Information

• Chemical Name: (2aS,4R,8aS)-8-allyloxycarbonyl-4-[(R)-6-benzyloxyheptyl]-7-methyl-1,2,2a,5,6,7,8,8a-octahydro-5,6,8b-triazaacenaphtylen-8b-ylium
• CAS No.: 865777-39-5
• Molecular Formula: C₂₈H₄₀N₃O₃
• Molecular Weight: 466.644
• Mol file: 865777-39-5.mol

Synonyms:(2aS,4R,8aS)-8-allyloxycarbonyl-4-[(R)-6-benzyloxyheptyl]-7-methyl-1,2,2a,5,6,7,8,8a-octahydro-5,6,8b-triazaacenaphtylen-8b-ylium

Chemical Property of (2aS,4R,8aS)-8-allyloxycarbonyl-4-[(R)-6-benzyloxyheptyl]-7-methyl-1,2,2a,5,6,7,8,8a-octahydro-5,6,8b-triazaacenaphtylen-8b-ylium

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2aS,4R,8aS)-8-allyloxycarbonyl-4-[(R)-6-benzyloxyheptyl]-7-methyl-1,2,2a,5,6,7,8,8a-octahydro-5,6,8b-triazaacenaphtylen-8b-ylium

There total 3 articles about (2aS,4R,8aS)-8-allyloxycarbonyl-4-[(R)-6-benzyloxyheptyl]-7-methyl-1,2,2a,5,6,7,8,8a-octahydro-5,6,8b-triazaacenaphtylen-8b-ylium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4aS,7S)-7-((2S,8R)-8-Benzyloxy-2-methanesulfonyloxy-nonyl)-1-imino-3-methyl-1,2,4a,5,6,7-hexahydro-pyrrolo[1,2-c]pyrimidine-4-carboxylic acid allyl ester; hydrochloride → (2aS,4R,8aS)-8-allyloxycarbonyl-4-[(R)-6-benzyloxyheptyl]-7-methyl-1,2,2a,5,6,7,8,8a-octahydro-5,6,8b-triazaacenaphtylen-8b-ylium (865777-39-5)

Guidance literature:

With triethylamine; In chloroform; at 70 ℃; for 48h;

DOI:10.1021/ja0574320

Reference yield:

(4aS,7S)-7-[(2S,8R)-8-benzyloxy-2-hydroxynonyl]-1-imino-3-methyl-1,2,4a,5,6,7-hexahydropyrrolo[1,2-c]pyrimidine-4-carboxylic acid allyl ester acetic acid salt → (2aS,4R,8aS)-8-allyloxycarbonyl-4-[(R)-6-benzyloxyheptyl]-7-methyl-1,2,2a,5,6,7,8,8a-octahydro-5,6,8b-triazaacenaphtylen-8b-ylium (865777-39-5)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂ / 2 h / 0 °C

2: 135 mg / Et₃N / CHCl₃ / 48 h / 70 °C

With triethylamine; In dichloromethane; chloroform;

DOI:10.1021/ja0574320

Reference yield:

allyl acetoacetate (1118-84-9) → (2aS,4R,8aS)-8-allyloxycarbonyl-4-[(R)-6-benzyloxyheptyl]-7-methyl-1,2,2a,5,6,7,8,8a-octahydro-5,6,8b-triazaacenaphtylen-8b-ylium (865777-39-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 150 mg / morpholinum acetate; Na₂SO₄ / 2,2,2-trifluoro-ethanol / 48 h / 60 °C

2: Et₃N / CH₂Cl₂ / 2 h / 0 °C

3: 135 mg / Et₃N / CHCl₃ / 48 h / 70 °C

With morpholinium acetate; sodium sulfate; triethylamine; In dichloromethane; chloroform; 2,2,2-trifluoroethanol; 1: Biginelli reaction;

DOI:10.1021/ja0574320

upstream raw materials:

allyl acetoacetate