5-[2-(3-diethylaminopropyl)-4-fluorobenzenesulfonylamino]-7-fluoro-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid

Base Information

Chemical Name:5-[2-(3-diethylaminopropyl)-4-fluorobenzenesulfonylamino]-7-fluoro-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid
CAS No.:1609122-56-6
Molecular Formula:C₂₄H₂₈F₂N₂O₅S
Molecular Weight:494.56
Hs Code.:

Synonyms:5-[2-(3-diethylaminopropyl)-4-fluorobenzenesulfonylamino]-7-fluoro-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid

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Chemical Property of 5-[2-(3-diethylaminopropyl)-4-fluorobenzenesulfonylamino]-7-fluoro-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid

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Technology Process of 5-[2-(3-diethylaminopropyl)-4-fluorobenzenesulfonylamino]-7-fluoro-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid

There total 15 articles about 5-[2-(3-diethylaminopropyl)-4-fluorobenzenesulfonylamino]-7-fluoro-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1609122-59-9
5-[2-((E)-3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonylamino]-7-fluoro-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid

: 1609122-56-6
5-[2-(3-diethylaminopropyl)-4-fluorobenzenesulfonylamino]-7-fluoro-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid

Guidance literature:: With 20% palladium hydroxide-activated charcoal; hydrogen; In ethyl acetate; at 20 ℃; for 2h; Inert atmosphere;

Reference yield:

: 1609122-71-5
5-[2-((Z)-3-diethylaminoprop-1-enyl)-4-fluorobenzenesulfonyl-amino]-7-fluoro-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid

: 1609122-56-6
5-[2-(3-diethylaminopropyl)-4-fluorobenzenesulfonylamino]-7-fluoro-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide monohydrate; water / 1,4-dioxane / 20 h / 100 °C / Inert atmosphere

2: 20% palladium hydroxide-activated charcoal; hydrogen / ethyl acetate / 2 h / 20 °C / Inert atmosphere

With lithium hydroxide monohydrate; 20% palladium hydroxide-activated charcoal; water; hydrogen; In 1,4-dioxane; ethyl acetate;

Reference yield:

: 681247-87-0,681247-88-1
N,N-diethyl-N-((Z)-1-tributylstannanylprop-1-en-3-yl)-amine

: 1609122-56-6
5-[2-(3-diethylaminopropyl)-4-fluorobenzenesulfonylamino]-7-fluoro-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: tri tert-butylphosphoniumtetrafluoroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / dimethyl sulfoxide; 1,4-dioxane / 3.25 h / 75 °C / Inert atmosphere

2: lithium hydroxide monohydrate; water / 1,4-dioxane / 20 h / 100 °C / Inert atmosphere

3: 20% palladium hydroxide-activated charcoal; hydrogen / ethyl acetate / 2 h / 20 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium hydroxide monohydrate; 20% palladium hydroxide-activated charcoal; water; hydrogen; tri tert-butylphosphoniumtetrafluoroborate; In 1,4-dioxane; dimethyl sulfoxide; ethyl acetate;