3-ethyl-8-{1-[5-oxo-1-(3-trifluoromethylphenyl)pyrrolidin-3-ylmethyl]-1H-pyrazol-4-yl}-1-propyl-3,7-dihydropurine-2,6-dione

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Chemical Name:3-ethyl-8-{1-[5-oxo-1-(3-trifluoromethylphenyl)pyrrolidin-3-ylmethyl]-1H-pyrazol-4-yl}-1-propyl-3,7-dihydropurine-2,6-dione
CAS No.:1188542-18-8
Molecular Formula:C₂₅H₂₆F₃N₇O₃
Molecular Weight:529.522
Hs Code.:

Synonyms:3-ethyl-8-{1-[5-oxo-1-(3-trifluoromethylphenyl)pyrrolidin-3-ylmethyl]-1H-pyrazol-4-yl}-1-propyl-3,7-dihydropurine-2,6-dione

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Chemical Property of 3-ethyl-8-{1-[5-oxo-1-(3-trifluoromethylphenyl)pyrrolidin-3-ylmethyl]-1H-pyrazol-4-yl}-1-propyl-3,7-dihydropurine-2,6-dione

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Technology Process of 3-ethyl-8-{1-[5-oxo-1-(3-trifluoromethylphenyl)pyrrolidin-3-ylmethyl]-1H-pyrazol-4-yl}-1-propyl-3,7-dihydropurine-2,6-dione

There total 10 articles about 3-ethyl-8-{1-[5-oxo-1-(3-trifluoromethylphenyl)pyrrolidin-3-ylmethyl]-1H-pyrazol-4-yl}-1-propyl-3,7-dihydropurine-2,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₁H₄₀F₃N₇O₄Si

: 1188542-18-8
3-ethyl-8-{1-[5-oxo-1-(3-trifluoromethylphenyl)pyrrolidin-3-ylmethyl]-1H-pyrazol-4-yl}-1-propyl-3,7-dihydropurine-2,6-dione

Guidance literature:: With hydrogenchloride; In ethanol; water; for 3h; Reflux;
DOI:10.1016/j.ejmech.2016.11.007

Reference yield:

: 98-16-8
3-trifluoromethylaniline

: 1188542-18-8
3-ethyl-8-{1-[5-oxo-1-(3-trifluoromethylphenyl)pyrrolidin-3-ylmethyl]-1H-pyrazol-4-yl}-1-propyl-3,7-dihydropurine-2,6-dione

Guidance literature:: Multi-step reaction with 6 steps

1.1: 2.5 h / 120 - 130 °C / Sealed tube

1.2: 0.33 h / Sealed tube

2.1: thionyl chloride / 2 h / 55 - 60 °C

3.1: sodium tetrahydroborate / ethanol / 3.5 h / 10 - 25 °C

4.1: triethylamine / dichloromethane / 0.25 h / 0 °C

4.2: 1.5 h / 10 - 15 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 75 - 80 °C

6.1: hydrogenchloride / ethanol; water / 3 h / Reflux

With hydrogenchloride; sodium tetrahydroborate; thionyl chloride; potassium carbonate; triethylamine; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2016.11.007

Reference yield:

: C₁₂H₁₂F₃NO₂

: 1188542-18-8
3-ethyl-8-{1-[5-oxo-1-(3-trifluoromethylphenyl)pyrrolidin-3-ylmethyl]-1H-pyrazol-4-yl}-1-propyl-3,7-dihydropurine-2,6-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 0.25 h / 0 °C

1.2: 1.5 h / 10 - 15 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 75 - 80 °C

3.1: hydrogenchloride / ethanol; water / 3 h / Reflux

With hydrogenchloride; potassium carbonate; triethylamine; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2016.11.007