2-amino-3-<4-chlorophenyl>-4-imino-5,6,7,8-tetrahydro<1>benzothieno<2,3-d>pyrimidine

Base Information

• Chemical Name: 2-amino-3-<4-chlorophenyl>-4-imino-5,6,7,8-tetrahydro<1>benzothieno<2,3-d>pyrimidine
• CAS No.: 143770-36-9
• Molecular Formula: C₁₆H₁₅ClN₄S
• Molecular Weight: 330.841

Synonyms:2-amino-3-<4-chlorophenyl>-4-imino-5,6,7,8-tetrahydro<1>benzothieno<2,3-d>pyrimidine

Chemical Property of 2-amino-3-<4-chlorophenyl>-4-imino-5,6,7,8-tetrahydro<1>benzothieno<2,3-d>pyrimidine

Chemical Property:

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Technology Process of 2-amino-3-<4-chlorophenyl>-4-imino-5,6,7,8-tetrahydro<1>benzothieno<2,3-d>pyrimidine

There total 4 articles about 2-amino-3-<4-chlorophenyl>-4-imino-5,6,7,8-tetrahydro<1>benzothieno<2,3-d>pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

4-<4-chlorophenyl>-5-imino-6,7,8,9-tetrahydro<1>benzothieno<3,2-e>tetrazolo<1,5-a>pyrimidine (143770-22-3) → 2-amino-3-<4-chlorophenyl>-4-imino-5,6,7,8-tetrahydro<1>benzothieno<2,3-d>pyrimidine (143770-36-9)

Guidance literature:

With acetic acid; zinc; a) RT, 3 h, b) 80 deg C to 90 deg C, 3 h;

DOI:10.1002/jhet.5570290435

Reference yield: 20.0%

3-cyano-2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene (4651-91-6) + N-(4-chlorophenyl)cyanamide (13463-94-0) → 2-amino-3-<4-chlorophenyl>-4-imino-5,6,7,8-tetrahydro<1>benzothieno<2,3-d>pyrimidine (143770-36-9) + 2-amino-3-(4-chlorophenyl)-5,6,7,8-tetrahydrobenzothieno<2,3-d>pyrimidin-4(3H)-one

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; Ambient temperature;

DOI:10.1002/jhet.5570300226

Reference yield:

2-chloro-3-<4-chlorophenyl>-4-imino-5,6,7,8-tetrahydro<1>benzothieno<2,3-d>pyrimidine hydrochloride → 2-amino-3-<4-chlorophenyl>-4-imino-5,6,7,8-tetrahydro<1>benzothieno<2,3-d>pyrimidine (143770-36-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 69 percent / NH₄Cl, NaN₃ / dimethylsulfoxide / 0.75 h

2: 33 percent / Zn, glacial acetic acid / a) RT, 3 h, b) 80 deg C to 90 deg C, 3 h

With sodium azide; ammonium chloride; acetic acid; zinc; In dimethyl sulfoxide;

DOI:10.1002/jhet.5570290435

upstream raw materials:

3-cyano-2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene

N-(4-chlorophenyl)cyanamide

4-<4-chlorophenyl>-5-imino-6,7,8,9-tetrahydro<1>benzothieno<3,2-e>tetrazolo<1,5-a>pyrimidine

N-dichloromethylene-4-chloroaniline

Downstream raw materials:

4-amino-2-<4-chlorophenyl>amino-5,6,7,8-tetrahydro<1>benzothieno<2,3-d>pyrimidine

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