methyl 3-(8-{4-[2-(4-{[3-(hexahydro-1H-azepin-1-yl)propyl]oxy}phenyl)ethyl]-1-piperazinyl}-2-quinolinyl)propanoate

Base Information

Chemical Name:methyl 3-(8-{4-[2-(4-{[3-(hexahydro-1H-azepin-1-yl)propyl]oxy}phenyl)ethyl]-1-piperazinyl}-2-quinolinyl)propanoate
CAS No.:958651-27-9
Molecular Formula:C₃₄H₄₆N₄O₃
Molecular Weight:558.764
Hs Code.:

Synonyms:methyl 3-(8-{4-[2-(4-{[3-(hexahydro-1H-azepin-1-yl)propyl]oxy}phenyl)ethyl]-1-piperazinyl}-2-quinolinyl)propanoate

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Chemical Property of methyl 3-(8-{4-[2-(4-{[3-(hexahydro-1H-azepin-1-yl)propyl]oxy}phenyl)ethyl]-1-piperazinyl}-2-quinolinyl)propanoate

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Technology Process of methyl 3-(8-{4-[2-(4-{[3-(hexahydro-1H-azepin-1-yl)propyl]oxy}phenyl)ethyl]-1-piperazinyl}-2-quinolinyl)propanoate

There total 10 articles about methyl 3-(8-{4-[2-(4-{[3-(hexahydro-1H-azepin-1-yl)propyl]oxy}phenyl)ethyl]-1-piperazinyl}-2-quinolinyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 958651-37-1
methyl 3-[8-(1-piperazinyl)-2-quinolinyl] propanoate

: 955359-98-5
2-(4-{[3-(hexahydro-1H-azepin-1-yl)propyl]oxy}phenyl)ethyl methanesulfonate

: 958651-27-9
methyl 3-(8-{4-[2-(4-{[3-(hexahydro-1H-azepin-1-yl)propyl]oxy}phenyl)ethyl]-1-piperazinyl}-2-quinolinyl)propanoate

Guidance literature:: With sodium hydrogencarbonate; In acetonitrile; at 80 ℃;

Reference yield:

: 958651-23-5
methyl (2E)-3-(8-{4-[2-(4-{[3-(hexahydro-1H-azepin-1-yl)propyl]oxy}phenyl)ethyl]-1-piperazinyl}-2-quinolinyl)-2-propenoate

: 958651-25-7
ethyl (2E)-3-(8-{4-[2-(4-{[3-(hexahydro-1H-azepin-1-yl)propyl]oxy}phenyl)ethyl]-1-piperazinyl}-2-quinolinyl)-2-propenoate

: 958651-27-9
methyl 3-(8-{4-[2-(4-{[3-(hexahydro-1H-azepin-1-yl)propyl]oxy}phenyl)ethyl]-1-piperazinyl}-2-quinolinyl)propanoate

: 958651-29-1
ethyl 3-(8-{4-[2-(4-{[3-(hexahydro-1H-azepin-1-yl)propyl]oxy}phenyl)ethyl]-1-piperazinyl}-2-quinolinyl)propanoate

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethyl acetate;

Reference yield:

: 958651-33-7
methyl 3-(8-{[(trifluoromethyl)sulfonyl]oxy}-2-quinolinyl)propanoate

: 958651-27-9
methyl 3-(8-{4-[2-(4-{[3-(hexahydro-1H-azepin-1-yl)propyl]oxy}phenyl)ethyl]-1-piperazinyl}-2-quinolinyl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; DavePhos / tetrahydrofuran / 80 °C

2: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

3: sodium hydrogencarbonate / acetonitrile / 80 °C

With sodium hydrogencarbonate; caesium carbonate; trifluoroacetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; DavePhos; In tetrahydrofuran; dichloromethane; acetonitrile;