6-(4-((E)-3-(4-(4-chlorophenyl)piperazin-1-yl)-3-oxoprop-1-enyl)-1-phenyl-1H-pyrazole-3-yl)-3-methyl-2-oxo-3H-benzoxazolone

Base Information

Chemical Name:6-(4-((E)-3-(4-(4-chlorophenyl)piperazin-1-yl)-3-oxoprop-1-enyl)-1-phenyl-1H-pyrazole-3-yl)-3-methyl-2-oxo-3H-benzoxazolone
CAS No.:1393571-52-2
Molecular Formula:C₃₀H₂₆ClN₅O₃
Molecular Weight:540.021
Hs Code.:

Synonyms:6-(4-((E)-3-(4-(4-chlorophenyl)piperazin-1-yl)-3-oxoprop-1-enyl)-1-phenyl-1H-pyrazole-3-yl)-3-methyl-2-oxo-3H-benzoxazolone

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Chemical Property of 6-(4-((E)-3-(4-(4-chlorophenyl)piperazin-1-yl)-3-oxoprop-1-enyl)-1-phenyl-1H-pyrazole-3-yl)-3-methyl-2-oxo-3H-benzoxazolone

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Technology Process of 6-(4-((E)-3-(4-(4-chlorophenyl)piperazin-1-yl)-3-oxoprop-1-enyl)-1-phenyl-1H-pyrazole-3-yl)-3-methyl-2-oxo-3H-benzoxazolone

There total 6 articles about 6-(4-((E)-3-(4-(4-chlorophenyl)piperazin-1-yl)-3-oxoprop-1-enyl)-1-phenyl-1H-pyrazole-3-yl)-3-methyl-2-oxo-3H-benzoxazolone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 38212-33-8
4-(4-chlorophenyl) piperazine

: 1393571-49-7
(E)-3-(3-(2,3-dihydro-3-methyl-2-oxo-3H-benzoxazole-6-yl)-1-phenyl-1H-pyrazole-4-yl)acrylic acid

: 1393571-52-2
6-(4-((E)-3-(4-(4-chlorophenyl)piperazin-1-yl)-3-oxoprop-1-enyl)-1-phenyl-1H-pyrazole-3-yl)-3-methyl-2-oxo-3H-benzoxazolone

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; at 20 ℃;
DOI:10.3906/kim-1110-8

Reference yield:

: 21892-80-8
3-methylbenzo[d]oxazol-2(3H)-one

: 1393571-52-2
6-(4-((E)-3-(4-(4-chlorophenyl)piperazin-1-yl)-3-oxoprop-1-enyl)-1-phenyl-1H-pyrazole-3-yl)-3-methyl-2-oxo-3H-benzoxazolone

Guidance literature:: Multi-step reaction with 5 steps

1: PPA / 0.37 h / 90 °C / Microwave irradiation

2: acetic acid / ethanol / 2 h / Reflux

3: trichlorophosphate / 50 °C / Cooling with ice; Microwave irradiation

4: piperidine; pyridine / 0.25 h / 115 °C / Microwave irradiation

5: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran; dichloromethane / 20 °C

With piperidine; pyridine; dmap; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trichlorophosphate; In tetrahydrofuran; ethanol; dichloromethane; 1: Friedel Crafts acylation / 4: Knoevenagel condensation;
DOI:10.3906/kim-1110-8

Reference yield:

: 59-49-4
2-Benzoxazolinone

: 1393571-52-2
6-(4-((E)-3-(4-(4-chlorophenyl)piperazin-1-yl)-3-oxoprop-1-enyl)-1-phenyl-1H-pyrazole-3-yl)-3-methyl-2-oxo-3H-benzoxazolone

Guidance literature:: Multi-step reaction with 6 steps

1: sodium hydroxide / 0.5 h

2: PPA / 0.37 h / 90 °C / Microwave irradiation

3: acetic acid / ethanol / 2 h / Reflux

4: trichlorophosphate / 50 °C / Cooling with ice; Microwave irradiation

5: piperidine; pyridine / 0.25 h / 115 °C / Microwave irradiation

6: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran; dichloromethane / 20 °C

With piperidine; pyridine; dmap; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; ethanol; dichloromethane; 2: Friedel Crafts acylation / 5: Knoevenagel condensation;
DOI:10.3906/kim-1110-8