4-(tetrahydro-pyran-4-ylmethyl)-2-(2,4,6-trimethyl-phenyl)-cyclopentane-1,3-dione

Base Information

Chemical Name:4-(tetrahydro-pyran-4-ylmethyl)-2-(2,4,6-trimethyl-phenyl)-cyclopentane-1,3-dione
CAS No.:1203552-33-3
Molecular Formula:C₂₀H₂₆O₃
Molecular Weight:314.425
Hs Code.:

Synonyms:4-(tetrahydro-pyran-4-ylmethyl)-2-(2,4,6-trimethyl-phenyl)-cyclopentane-1,3-dione

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Chemical Property of 4-(tetrahydro-pyran-4-ylmethyl)-2-(2,4,6-trimethyl-phenyl)-cyclopentane-1,3-dione

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Technology Process of 4-(tetrahydro-pyran-4-ylmethyl)-2-(2,4,6-trimethyl-phenyl)-cyclopentane-1,3-dione

There total 5 articles about 4-(tetrahydro-pyran-4-ylmethyl)-2-(2,4,6-trimethyl-phenyl)-cyclopentane-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1203556-27-7
4-[1-(tetrahydro-pyran-4-yl)-meth-(E)-ylidene]-2-(2,4,6-trimethyl-phenyl)-cyclopentane-1,3-dione

: 1203552-33-3
4-(tetrahydro-pyran-4-ylmethyl)-2-(2,4,6-trimethyl-phenyl)-cyclopentane-1,3-dione

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethanol; at 20 ℃; for 5h; under 2250.23 Torr;

Reference yield:

: 5980-97-2
mesitylboronic acid

: 1203552-33-3
4-(tetrahydro-pyran-4-ylmethyl)-2-(2,4,6-trimethyl-phenyl)-cyclopentane-1,3-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium phosphate / palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / toluene / 4 h / 90 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 0.83 h / -78 °C / Inert atmosphere

2.2: 1.5 h / -78 - 20 °C

3.1: hydrogenchloride; water / acetone / 1.5 h / 130 °C / microwave irradiation

4.1: hydrogen / palladium 10% on activated carbon / ethanol / 5 h / 20 °C / 2250.23 Torr

With hydrogenchloride; potassium phosphate; n-butyllithium; water; hydrogen; N-ethyl-N,N-diisopropylamine; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium 10% on activated carbon; palladium diacetate; In tetrahydrofuran; ethanol; hexane; acetone; toluene;

Reference yield:

: 14203-25-9
2-bromo-3-methoxy-cyclopent-2-en-1-one

: 1203552-33-3
4-(tetrahydro-pyran-4-ylmethyl)-2-(2,4,6-trimethyl-phenyl)-cyclopentane-1,3-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium phosphate / palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / toluene / 4 h / 90 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 0.83 h / -78 °C / Inert atmosphere

2.2: 1.5 h / -78 - 20 °C

3.1: hydrogenchloride; water / acetone / 1.5 h / 130 °C / microwave irradiation

4.1: hydrogen / palladium 10% on activated carbon / ethanol / 5 h / 20 °C / 2250.23 Torr

With hydrogenchloride; potassium phosphate; n-butyllithium; water; hydrogen; N-ethyl-N,N-diisopropylamine; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium 10% on activated carbon; palladium diacetate; In tetrahydrofuran; ethanol; hexane; acetone; toluene;