(2E,4E,6E)-7-(4,4-Dimethyl-thiochroman-6-yl)-3-methyl-octa-2,4,6-trienoyl chloride

Base Information

• Chemical Name: (2E,4E,6E)-7-(4,4-Dimethyl-thiochroman-6-yl)-3-methyl-octa-2,4,6-trienoyl chloride
• CAS No.: 108695-21-2
• Molecular Formula: C₂₀H₂₃ClOS
• Molecular Weight: 346.921
• Mol file: 108695-21-2.mol

Synonyms:(2E,4E,6E)-7-(4,4-Dimethyl-thiochroman-6-yl)-3-methyl-octa-2,4,6-trienoyl chloride

Chemical Property of (2E,4E,6E)-7-(4,4-Dimethyl-thiochroman-6-yl)-3-methyl-octa-2,4,6-trienoyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2E,4E,6E)-7-(4,4-Dimethyl-thiochroman-6-yl)-3-methyl-octa-2,4,6-trienoyl chloride

There total 1 articles about (2E,4E,6E)-7-(4,4-Dimethyl-thiochroman-6-yl)-3-methyl-octa-2,4,6-trienoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl methyl ketone (88579-23-1) → (2E,4E,6E)-7-(4,4-Dimethyl-thiochroman-6-yl)-3-methyl-octa-2,4,6-trienoyl chloride (108695-21-2)

Guidance literature:

Multi-step reaction with 5 steps

1: tetrahydrofuran / 1.) reflux, 1 h, 2.) RT, 10 h

2: 98.8 percent / methanol / 3 h / Ambient temperature

3: n-butyllithium / diethyl ether / 24 h / Ambient temperature

4: KOH, water / ethanol / 1 h / Heating

5: pyridine, SOCl₂ / ethanol / 1 h / Ambient temperature

With pyridine; potassium hydroxide; n-butyllithium; thionyl chloride; water; In tetrahydrofuran; methanol; diethyl ether; ethanol;

DOI:10.1021/jm00391a033

upstream raw materials:

3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl methyl ketone