N-[(1R,2S)-2-(hydroxycarbamoyl)cyclohexyl]-6-[(2-trifluoromethyl-1H-benzimidazol-1-yl)methyl]nicotinamide

Base Information

Chemical Name:N-[(1R,2S)-2-(hydroxycarbamoyl)cyclohexyl]-6-[(2-trifluoromethyl-1H-benzimidazol-1-yl)methyl]nicotinamide
CAS No.:1346159-34-9
Molecular Formula:C₂₂H₂₂F₃N₅O₃
Molecular Weight:461.444
Hs Code.:

Synonyms:N-[(1R,2S)-2-(hydroxycarbamoyl)cyclohexyl]-6-[(2-trifluoromethyl-1H-benzimidazol-1-yl)methyl]nicotinamide

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Chemical Property of N-[(1R,2S)-2-(hydroxycarbamoyl)cyclohexyl]-6-[(2-trifluoromethyl-1H-benzimidazol-1-yl)methyl]nicotinamide

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Technology Process of N-[(1R,2S)-2-(hydroxycarbamoyl)cyclohexyl]-6-[(2-trifluoromethyl-1H-benzimidazol-1-yl)methyl]nicotinamide

There total 5 articles about N-[(1R,2S)-2-(hydroxycarbamoyl)cyclohexyl]-6-[(2-trifluoromethyl-1H-benzimidazol-1-yl)methyl]nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₃H₂₃F₃N₄O₃

: 1346159-34-9
N-[(1R,2S)-2-(hydroxycarbamoyl)cyclohexyl]-6-[(2-trifluoromethyl-1H-benzimidazol-1-yl)methyl]nicotinamide

Guidance literature:: C₂₃H₂₃F₃N₄O₃; With hydroxylamine hydrochloride; potassium hydroxide; In methanol; at 20 ℃; for 3h;

With hydrogenchloride; In water; at 0 ℃; pH=6;
DOI:10.1016/j.ejmech.2011.09.018

Reference yield:

: 1346159-30-5
C₁₅H₁₀F₃N₃O₂

: 1346159-34-9
N-[(1R,2S)-2-(hydroxycarbamoyl)cyclohexyl]-6-[(2-trifluoromethyl-1H-benzimidazol-1-yl)methyl]nicotinamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 12 h / 20 °C

2.1: hydroxylamine hydrochloride; potassium hydroxide / methanol / 3 h / 20 °C

2.2: 0 °C / pH 6

With hydroxylamine hydrochloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2011.09.018

Reference yield:

: 49668-90-8
methyl 6-(chloromethyl)pyridine-3-carboxylate

: 1346159-34-9
N-[(1R,2S)-2-(hydroxycarbamoyl)cyclohexyl]-6-[(2-trifluoromethyl-1H-benzimidazol-1-yl)methyl]nicotinamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

2.1: sodium hydroxide / tetrahydrofuran; methanol / 1 h / 20 °C

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 12 h / 20 °C

4.1: hydroxylamine hydrochloride; potassium hydroxide / methanol / 3 h / 20 °C

4.2: 0 °C / pH 6

With hydroxylamine hydrochloride; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2011.09.018