1-(3-Bromo-phenyl)-3-phenyl-1,5-dihydro-pyrazolo[4,3-c]quinolin-4-one

Base Information

• Chemical Name: 1-(3-Bromo-phenyl)-3-phenyl-1,5-dihydro-pyrazolo[4,3-c]quinolin-4-one
• CAS No.: 109334-69-2
• Molecular Formula: C₂₂H₁₄BrN₃O
• Molecular Weight: 416.277
• Mol file: 109334-69-2.mol

Synonyms:1-(3-Bromo-phenyl)-3-phenyl-1,5-dihydro-pyrazolo[4,3-c]quinolin-4-one

Chemical Property of 1-(3-Bromo-phenyl)-3-phenyl-1,5-dihydro-pyrazolo[4,3-c]quinolin-4-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(3-Bromo-phenyl)-3-phenyl-1,5-dihydro-pyrazolo[4,3-c]quinolin-4-one

There total 6 articles about 1-(3-Bromo-phenyl)-3-phenyl-1,5-dihydro-pyrazolo[4,3-c]quinolin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl (2-nitrobenzoyl)benzoylacetate (109334-61-4) → 1-(3-Bromo-phenyl)-3-phenyl-1,5-dihydro-pyrazolo[4,3-c]quinolin-4-one (109334-69-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 41 percent / Et₃N / methanol / 6 h / Heating

2: 1.) H₂ / 1.) 10percent Pd/C / 1.) EtOAc, 50 psi, 12 h, 2.) 150 deg C, 30 min

With hydrogen; triethylamine; palladium on activated charcoal; In methanol;

DOI:10.1021/jm00393a009

Reference yield:

3-bromophenylhydrazine hydrochloride (27246-81-7) → 1-(3-Bromo-phenyl)-3-phenyl-1,5-dihydro-pyrazolo[4,3-c]quinolin-4-one (109334-69-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 41 percent / Et₃N / methanol / 6 h / Heating

2: 1.) H₂ / 1.) 10percent Pd/C / 1.) EtOAc, 50 psi, 12 h, 2.) 150 deg C, 30 min

With hydrogen; triethylamine; palladium on activated charcoal; In methanol;

DOI:10.1021/jm00393a009

Reference yield:

1-(3-Bromo-phenyl)-5-(2-nitro-phenyl)-3-phenyl-1H-pyrazole-4-carboxylic acid methyl ester (109334-57-8) → 1-(3-Bromo-phenyl)-3-phenyl-1,5-dihydro-pyrazolo[4,3-c]quinolin-4-one (109334-69-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; Yield given. Multistep reaction; 1.) EtOAc, 50 psi, 12 h, 2.) 150 deg C, 30 min;

DOI:10.1021/jm00393a009

upstream raw materials:

1-(3-Bromo-phenyl)-5-(2-nitro-phenyl)-3-phenyl-1H-pyrazole-4-carboxylic acid methyl ester

1-(3-Bromo-phenyl)-5-(2-nitro-phenyl)-3-phenyl-1H-pyrazole-4-carboxylic acid ethyl ester

(E)-methyl 2-nitrocinnamate

ethyl (2-nitrobenzoyl)benzoylacetate

Downstream raw materials:

1-(3-Bromo-phenyl)-5-methyl-3-phenyl-1,5-dihydro-pyrazolo[4,3-c]quinolin-4-one