trifluoro-methanesulfonic acid 8-(3-chloro-phenyl)-[1,7]naphthyridin-6-yl ester

Base Information

Chemical Name:trifluoro-methanesulfonic acid 8-(3-chloro-phenyl)-[1,7]naphthyridin-6-yl ester
CAS No.:207279-18-3
Molecular Formula:C₁₅H₈ClF₃N₂O₃S
Molecular Weight:388.754
Hs Code.:

Synonyms:trifluoro-methanesulfonic acid 8-(3-chloro-phenyl)-[1,7]naphthyridin-6-yl ester

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Chemical Property of trifluoro-methanesulfonic acid 8-(3-chloro-phenyl)-[1,7]naphthyridin-6-yl ester

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Technology Process of trifluoro-methanesulfonic acid 8-(3-chloro-phenyl)-[1,7]naphthyridin-6-yl ester

There total 3 articles about trifluoro-methanesulfonic acid 8-(3-chloro-phenyl)-[1,7]naphthyridin-6-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 1493-13-6
trifluorormethanesulfonic acid

: 207279-13-8
8-(3-chlorophenyl)-[1,7]naphthyridin-6-ylamine

: 207279-18-3
trifluoro-methanesulfonic acid 8-(3-chloro-phenyl)-[1,7]naphthyridin-6-yl ester

Guidance literature:: With sodium nitrite; In N,N-dimethyl-formamide; at 25 ℃; for 3h;
DOI:10.1021/jm991094u

Reference yield:

: 5912-34-5
2-cyano-pyridin-3-yl-acetonitrile

: 207279-18-3
trifluoro-methanesulfonic acid 8-(3-chloro-phenyl)-[1,7]naphthyridin-6-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 74 percent / HBr / acetic acid / 1 h / 25 °C

2: 74 percent / bis(dibenzylideneacetone)palladium; triphenylphosphine; aq. K₂CO₃ / toluene; dimethylformamide / 4 h / Heating

3: 34 percent / sodium nitrite / dimethylformamide / 3 h / 25 °C

With hydrogen bromide; potassium carbonate; triphenylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; sodium nitrite; In acetic acid; N,N-dimethyl-formamide; toluene; 1: Cyclization / 2: Coupling / 3: Substitution;
DOI:10.1021/jm991094u

Reference yield:

: 6443-85-2
3-pyridinylacetonitrile

: 207279-18-3
trifluoro-methanesulfonic acid 8-(3-chloro-phenyl)-[1,7]naphthyridin-6-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1: dihydrogen peroxide; acetic acid / 2 h / 100 °C

2: N,N-Dimethylcarbamoyl chloride / toluene / 1.5 h / 80 °C

3: acetic acid; hydrogen bromide / 1 h / 35 °C

5: sodium nitrite

With hydrogen bromide; dihydrogen peroxide; acetic acid; N,N-Dimethylcarbamoyl chloride; sodium nitrite; In toluene; 4: |Suzuki Coupling;
DOI:10.1021/jm300459a