(S)-2-(((S)-tert-butoxycarbonylamino)(4-methoxyphenyl)methyl)-2-cyanocyclopentanone

Base Information

Chemical Name:(S)-2-(((S)-tert-butoxycarbonylamino)(4-methoxyphenyl)methyl)-2-cyanocyclopentanone
CAS No.:1123681-81-1
Molecular Formula:C₁₉H₂₄N₂O₄
Molecular Weight:344.411
Hs Code.:

Synonyms:(S)-2-(((S)-tert-butoxycarbonylamino)(4-methoxyphenyl)methyl)-2-cyanocyclopentanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-(((S)-tert-butoxycarbonylamino)(4-methoxyphenyl)methyl)-2-cyanocyclopentanone

Chemical Property:

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Technology Process of (S)-2-(((S)-tert-butoxycarbonylamino)(4-methoxyphenyl)methyl)-2-cyanocyclopentanone

There total 3 articles about (S)-2-(((S)-tert-butoxycarbonylamino)(4-methoxyphenyl)methyl)-2-cyanocyclopentanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 479423-40-0
N-tert-butyl 4-methoxybenzylidenecarbamate

: 2941-29-9,138260-51-2
2-oxocyclopentanecarbonitrile

: 1123681-81-1
(S)-2-(((S)-tert-butoxycarbonylamino)(4-methoxyphenyl)methyl)-2-cyanocyclopentanone

Guidance literature:: With erbium triisopropoxide; (S)-N-(2-hydroxyphenyl)-2-(2-hydroxybenzoylamino)-3-methylbutylamide; In diethyl ether; at 0 ℃; for 1h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1021/ja900084k

Reference yield:

: 479423-40-0
N-tert-butyl 4-methoxybenzylidenecarbamate

: 2941-29-9,138260-51-2
2-oxocyclopentanecarbonitrile

: 1123681-81-1
(S)-2-(((S)-tert-butoxycarbonylamino)(4-methoxyphenyl)methyl)-2-cyanocyclopentanone

: (R)-2-(((R)-tert-butoxycarbonylamino)(4-methoxyphenyl)methyl)-2-cyanocyclopentanone

Guidance literature:: With C₃₇H₃₁F₆N₃O; In toluene; at -78 ℃; for 1.16667h; optical yield given as %ee; enantioselective reaction;
DOI:10.1002/adsc.200900268

Reference yield:

: 479423-40-0
N-tert-butyl 4-methoxybenzylidenecarbamate

: 2941-29-9,138260-51-2
2-oxocyclopentanecarbonitrile

: 1123681-81-1
(S)-2-(((S)-tert-butoxycarbonylamino)(4-methoxyphenyl)methyl)-2-cyanocyclopentanone

: C₁₉H₂₄N₂O₄

Guidance literature:: With sodium hydrogencarbonate; In diethyl ether; at 0 ℃; for 1.5h; Reagent/catalyst; enantioselective reaction; Catalytic behavior; Molecular sieve; Flow reactor;
DOI:10.1002/chem.201406402