trans-4-{4-amino-5-[3-ethyl-5-fluoro-4-(hydroxymethyl)phenyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl}cyclohexanol

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Chemical Name:trans-4-{4-amino-5-[3-ethyl-5-fluoro-4-(hydroxymethyl)phenyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl}cyclohexanol
CAS No.:1417736-25-4
Molecular Formula:C₂₁H₂₅FN₄O₂
Molecular Weight:384.454
Hs Code.:

Synonyms:trans-4-{4-amino-5-[3-ethyl-5-fluoro-4-(hydroxymethyl)phenyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl}cyclohexanol

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Chemical Property of trans-4-{4-amino-5-[3-ethyl-5-fluoro-4-(hydroxymethyl)phenyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl}cyclohexanol

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Technology Process of trans-4-{4-amino-5-[3-ethyl-5-fluoro-4-(hydroxymethyl)phenyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl}cyclohexanol

There total 8 articles about trans-4-{4-amino-5-[3-ethyl-5-fluoro-4-(hydroxymethyl)phenyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl}cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 1417736-82-3
[2-ethyl-6-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanol

: 1417736-54-9
trans-4-(4-amino-5-bromopyrrolo[2,1-f][1,2,4]triazin-7-yl)cyclohexanol

: 1417736-25-4
trans-4-{4-amino-5-[3-ethyl-5-fluoro-4-(hydroxymethyl)phenyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl}cyclohexanol

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In water; acetonitrile; at 150 ℃; for 1h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 937046-98-5
7-bromo-pyrrolo[2,1-f][1,2,4]triazin-4-ylamine

: 1417736-25-4
trans-4-{4-amino-5-[3-ethyl-5-fluoro-4-(hydroxymethyl)phenyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl}cyclohexanol

Guidance literature:: Multi-step reaction with 7 steps

1.1: chloro-trimethyl-silane / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

1.2: 3 h / 0 - 20 °C

1.3: 16 h / 20 °C

2.1: trifluoroacetic anhydride; pyridine / 20 °C

3.1: hydrogen; palladium 10% on activated carbon / methanol / 24 h / 20 °C / 760.05 Torr

4.1: hydrogenchloride / methanol / 3 h / 0 °C

4.2: pH 6 - 7

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C

6.1: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / tetrahydrofuran / 1 h / -20 °C

7.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; acetonitrile / 1 h / 150 °C / Inert atmosphere; Microwave irradiation

With pyridine; hydrogenchloride; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; chloro-trimethyl-silane; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; palladium 10% on activated carbon; hydrogen; sodium carbonate; trifluoroacetic anhydride; In tetrahydrofuran; methanol; water; acetonitrile;

Reference yield:

: 1417736-50-5
7-(1 ,4-dioxaspiro[4.5]dec-7-en-8-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine

: 1417736-25-4
trans-4-{4-amino-5-[3-ethyl-5-fluoro-4-(hydroxymethyl)phenyl]pyrrolo[2,1-f][1,2,4]triazin-7-yl}cyclohexanol

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen; palladium 10% on activated carbon / methanol / 24 h / 20 °C / 760.05 Torr

2.1: hydrogenchloride / methanol / 3 h / 0 °C

2.2: pH 6 - 7

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C

4.1: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / tetrahydrofuran / 1 h / -20 °C

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; acetonitrile / 1 h / 150 °C / Inert atmosphere; Microwave irradiation

With hydrogenchloride; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; palladium 10% on activated carbon; hydrogen; sodium carbonate; In tetrahydrofuran; methanol; water; acetonitrile;