(2S,3R,4S,7R,8R)-1-(tert-butyldimethylsilyloxy)-7-hydroxy-3,8-bis(4-methoxybenzyloxy)-2,4,8-trimethylundec-10-en-5-one

Base Information

Chemical Name:(2S,3R,4S,7R,8R)-1-(tert-butyldimethylsilyloxy)-7-hydroxy-3,8-bis(4-methoxybenzyloxy)-2,4,8-trimethylundec-10-en-5-one
CAS No.:1087342-96-8
Molecular Formula:C₃₆H₅₆O₇Si
Molecular Weight:628.922
Hs Code.:

Synonyms:(2S,3R,4S,7R,8R)-1-(tert-butyldimethylsilyloxy)-7-hydroxy-3,8-bis(4-methoxybenzyloxy)-2,4,8-trimethylundec-10-en-5-one

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Chemical Property of (2S,3R,4S,7R,8R)-1-(tert-butyldimethylsilyloxy)-7-hydroxy-3,8-bis(4-methoxybenzyloxy)-2,4,8-trimethylundec-10-en-5-one

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Technology Process of (2S,3R,4S,7R,8R)-1-(tert-butyldimethylsilyloxy)-7-hydroxy-3,8-bis(4-methoxybenzyloxy)-2,4,8-trimethylundec-10-en-5-one

There total 2 articles about (2S,3R,4S,7R,8R)-1-(tert-butyldimethylsilyloxy)-7-hydroxy-3,8-bis(4-methoxybenzyloxy)-2,4,8-trimethylundec-10-en-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1087342-87-7
(R)-2-(4-methoxybenzyloxy)-2-methylpent-4-enal

: 1087342-95-7
C₂₂H₃₈O₄Si

: 1087342-96-8
(2S,3R,4S,7R,8R)-1-(tert-butyldimethylsilyloxy)-7-hydroxy-3,8-bis(4-methoxybenzyloxy)-2,4,8-trimethylundec-10-en-5-one

Guidance literature:: With diethylzinc; ((2S,2'S)-((2-hydroxy-5-methyl-1,3-phenylene)bis(methylene))bis(pyrrolidine-1,2-diyl))bis(diphenylmethanol); In 1,4-dioxane; hexane; for 45h; enantioselective reaction; Inert atmosphere; Molecular sieve;
DOI:10.1021/ja807127s

Reference yield:

: 1087342-87-7
(R)-2-(4-methoxybenzyloxy)-2-methylpent-4-enal

: 1087342-95-7
C₂₂H₃₈O₄Si

: 1087342-96-8
(2S,3R,4S,7R,8R)-1-(tert-butyldimethylsilyloxy)-7-hydroxy-3,8-bis(4-methoxybenzyloxy)-2,4,8-trimethylundec-10-en-5-one

: 1192033-97-8
C₁₄H₂₀O₃

: 1-(tert-butyldimethylsilyloxy)-7-hydroxy-3,8-bis(4-methoxybenzyloxy)-2,4,8-trimethylundec-10-en-5-one

Guidance literature:: C₂₂H₃₈O₄Si; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

(R)-2-(4-methoxybenzyloxy)-2-methylpent-4-enal; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;
DOI:10.1021/ja906056v

Reference yield:

: 1087342-96-8
(2S,3R,4S,7R,8R)-1-(tert-butyldimethylsilyloxy)-7-hydroxy-3,8-bis(4-methoxybenzyloxy)-2,4,8-trimethylundec-10-en-5-one

: C₃₆H₅₈O₇Si

Guidance literature:: With sodium tetrahydroborate; diethyl methoxy borane; In tetrahydrofuran; methanol; at -78 - 0 ℃; for 6.33333h; Inert atmosphere;
DOI:10.1021/ja807127s