ADR 882

Base Information

• Chemical Name: ADR 882
• CAS No.: 138559-57-6
• Molecular Formula: C₁₆H₂₀ClN₃O₂
• Molecular Weight: 321.807
• Mol file: 138559-57-6.mol

Synonyms:R-ADR 882

Chemical Property of ADR 882

Chemical Property:

• Vapor Pressure: 4.39E-08mmHg at 25°C
• Boiling Point: 444.1°Cat760mmHg
• Flash Point: 222.4°C
• PSA: 67.59000
• Density: 1.4g/cm³
• LogP: 2.59110

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ADR 882

There total 2 articles about ADR 882 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

quinuclidin-3-amine (76883-48-2,120570-05-0,123536-15-2,6238-14-8,781591-76-2) + (2E)-but-2-enedioic acid (110-17-8,26099-09-2) + 1,1'-carbonyldiimidazole (530-62-1) + 4-amino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxylic acid (123654-26-2) → N-(1-azabicyclo [2.2.2]oct-3-yl)-4-amino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxamide (138559-57-6)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; hydrogenchloride; methanol;

Reference yield:

(S)-3-aminoquinuclidine (120570-05-0,781591-76-2) + 4-amino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxylic acid (123654-26-2) → ADR-932 (138559-57-6)

Guidance literature:

With 1,1'-carbonyldiimidazole; Multistep reaction; 1.) THF, 40 deg C, 1 h, 2.) THF, 40 deg C, 2 h;

DOI:10.1016/0960-894X(96)00002-9

upstream raw materials:

(S)-3-aminoquinuclidine

4-amino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxylic acid

quinuclidin-3-amine

(2E)-but-2-enedioic acid