1-{5-[3-(difluoromethyl)-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl]-1,3-thiazol-2-yl}cyclobutanol

Base Information

Chemical Name:1-{5-[3-(difluoromethyl)-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl]-1,3-thiazol-2-yl}cyclobutanol
CAS No.:1312505-81-9
Molecular Formula:C₁₉H₁₅F₅N₄OS
Molecular Weight:442.412
Hs Code.:

Synonyms:1-{5-[3-(difluoromethyl)-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl]-1,3-thiazol-2-yl}cyclobutanol

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Chemical Property of 1-{5-[3-(difluoromethyl)-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl]-1,3-thiazol-2-yl}cyclobutanol

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Technology Process of 1-{5-[3-(difluoromethyl)-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl]-1,3-thiazol-2-yl}cyclobutanol

There total 6 articles about 1-{5-[3-(difluoromethyl)-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl]-1,3-thiazol-2-yl}cyclobutanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1312534-98-7
1-(5-bromo-1,3-thiazol-2-yl)cyclobutanol

: 1312537-08-8
N-[3-(difluoromethyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-4-(trifluoromethyl)pyrimidin-2-amine

: 1312505-81-9
1-{5-[3-(difluoromethyl)-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl]-1,3-thiazol-2-yl}cyclobutanol

Guidance literature:: With sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In N,N-dimethyl-formamide; at 85 ℃; for 3h;

Reference yield:

: 99-61-6
3-nitro-benzaldehyde

: 1312505-81-9
1-{5-[3-(difluoromethyl)-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl]-1,3-thiazol-2-yl}cyclobutanol

Guidance literature:: Multi-step reaction with 6 steps

1: diethylamino-sulfur trifluoride / dichloromethane / -78 - 20 °C

2: N-Bromosuccinimide; sulfuric acid / water / 1.5 h / 20 - 60 °C

3: ammonium chloride / iron / ethanol; water / 2 h / 95 °C

4: acetic acid / 1,4-dioxane / 16 h / 105 °C

5: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 16 h / 105 °C

6: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 3 h / 85 °C

With N-Bromosuccinimide; diethylamino-sulfur trifluoride; sulfuric acid; potassium acetate; sodium carbonate; ammonium chloride; acetic acid; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; iron; In 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; 6: Suzuki Coupling;

Reference yield:

: 403-25-8
1-(difluoromethyl)-3-nitrobenzene

: 1312505-81-9
1-{5-[3-(difluoromethyl)-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl]-1,3-thiazol-2-yl}cyclobutanol

Guidance literature:: Multi-step reaction with 5 steps

1: N-Bromosuccinimide; sulfuric acid / water / 1.5 h / 20 - 60 °C

2: ammonium chloride / iron / ethanol; water / 2 h / 95 °C

3: acetic acid / 1,4-dioxane / 16 h / 105 °C

4: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 16 h / 105 °C

5: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 3 h / 85 °C

With N-Bromosuccinimide; sulfuric acid; potassium acetate; sodium carbonate; ammonium chloride; acetic acid; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; iron; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; 5: Suzuki Coupling;