(S)-3-[4-(4-Carbamimidoyl-phenylamino)-butyrylamino]-pent-4-enoic acid ethyl ester

Base Information

Chemical Name:(S)-3-[4-(4-Carbamimidoyl-phenylamino)-butyrylamino]-pent-4-enoic acid ethyl ester
CAS No.:169237-91-6
Molecular Formula:C₁₈H₂₆N₄O₃
Molecular Weight:346.429
Hs Code.:

Synonyms:(S)-3-[4-(4-Carbamimidoyl-phenylamino)-butyrylamino]-pent-4-enoic acid ethyl ester

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Chemical Property of (S)-3-[4-(4-Carbamimidoyl-phenylamino)-butyrylamino]-pent-4-enoic acid ethyl ester

Chemical Property:

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Technology Process of (S)-3-[4-(4-Carbamimidoyl-phenylamino)-butyrylamino]-pent-4-enoic acid ethyl ester

There total 11 articles about (S)-3-[4-(4-Carbamimidoyl-phenylamino)-butyrylamino]-pent-4-enoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 14403-19-1
(RS)-3-amino-pent-4-enoic acid

: 169237-91-6
(S)-3-[4-(4-Carbamimidoyl-phenylamino)-butyrylamino]-pent-4-enoic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 1N aq. NaOH / 2-methyl-propan-2-ol / 2 h / 24 °C

3: 95 percent / SOCl₂ / 1 h / Heating

4: 1.) DSC, pyridine, DMAP, 2.) 4-methylpiperidine / 1.) acetonitrile, 23 deg C, 30 min, 2.) acetonitrile, 23 deg C, 3 h

5: triethylamine, H₂S, pyridine / 28 h / 23 °C

6: 1.) CH₃I, 2.) NH₄OAc / 1.) acetone, 56 deg C, 30 min, 2.) methanol, 65 deg C, 3 h

With pyridine; 4-methylpiperidin; dmap; sodium hydroxide; thionyl chloride; di(succinimido) carbonate; hydrogen sulfide; ammonium acetate; triethylamine; methyl iodide; In tert-butyl alcohol;
DOI:10.1021/jm00013a014

Reference yield:

: 62926-88-9
N-(4-cyanophenyl)-2,2,2-trifluoroacetamide

: 169237-91-6
(S)-3-[4-(4-Carbamimidoyl-phenylamino)-butyrylamino]-pent-4-enoic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 8.25 g / KI, K₂CO₃ / acetone / 4 h / 56 °C

2: 72.5 percent / 6N aq. HCl / dioxane / 20 h

3: 1.) DSC, pyridine, DMAP, 2.) 4-methylpiperidine / 1.) acetonitrile, 23 deg C, 30 min, 2.) acetonitrile, 23 deg C, 3 h

4: triethylamine, H₂S, pyridine / 28 h / 23 °C

5: 1.) CH₃I, 2.) NH₄OAc / 1.) acetone, 56 deg C, 30 min, 2.) methanol, 65 deg C, 3 h

With pyridine; 4-methylpiperidin; hydrogenchloride; dmap; di(succinimido) carbonate; hydrogen sulfide; ammonium acetate; potassium carbonate; triethylamine; potassium iodide; methyl iodide; In 1,4-dioxane; acetone;
DOI:10.1021/jm00013a014

Reference yield:

: 169237-59-6
4-[(4-Cyano-phenyl)-(2,2,2-trifluoro-acetyl)-amino]-butyric acid ethyl ester

: 169237-91-6
(S)-3-[4-(4-Carbamimidoyl-phenylamino)-butyrylamino]-pent-4-enoic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 72.5 percent / 6N aq. HCl / dioxane / 20 h

2: 1.) DSC, pyridine, DMAP, 2.) 4-methylpiperidine / 1.) acetonitrile, 23 deg C, 30 min, 2.) acetonitrile, 23 deg C, 3 h

3: triethylamine, H₂S, pyridine / 28 h / 23 °C

4: 1.) CH₃I, 2.) NH₄OAc / 1.) acetone, 56 deg C, 30 min, 2.) methanol, 65 deg C, 3 h

With pyridine; 4-methylpiperidin; hydrogenchloride; dmap; di(succinimido) carbonate; hydrogen sulfide; ammonium acetate; triethylamine; methyl iodide; In 1,4-dioxane;
DOI:10.1021/jm00013a014