3-[[2,6-difluoro-3-(3-fluorophenyl)phenyl]methylamino]-2,4-difluorophenol

Base Information

Chemical Name:3-[[2,6-difluoro-3-(3-fluorophenyl)phenyl]methylamino]-2,4-difluorophenol
CAS No.:1427407-40-6
Molecular Formula:C₁₉H₁₂F₅NO
Molecular Weight:365.302
Hs Code.:

Synonyms:3-[[2,6-difluoro-3-(3-fluorophenyl)phenyl]methylamino]-2,4-difluorophenol

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Chemical Property of 3-[[2,6-difluoro-3-(3-fluorophenyl)phenyl]methylamino]-2,4-difluorophenol

Chemical Property:

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Technology Process of 3-[[2,6-difluoro-3-(3-fluorophenyl)phenyl]methylamino]-2,4-difluorophenol

There total 9 articles about 3-[[2,6-difluoro-3-(3-fluorophenyl)phenyl]methylamino]-2,4-difluorophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1427407-39-3
N-(2,6-difluoro-3-hydroxy-phenyl)-2,6-difluoro-3-(3-fluorophenyl)benzamide

: 1427407-40-6
3-[[2,6-difluoro-3-(3-fluorophenyl)phenyl]methylamino]-2,4-difluorophenol

Guidance literature:: With borane-THF; In tetrahydrofuran; at 20 ℃; for 4h; Inert atmosphere; Reflux;

Reference yield:

: 1427407-36-0
methyl 2,6-difluoro-3-(trifluoromethylsulfonyloxy)benzoate

: 1427407-40-6
3-[[2,6-difluoro-3-(3-fluorophenyl)phenyl]methylamino]-2,4-difluorophenol

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; methanol / 80 °C / Inert atmosphere

2: water; sodium hydroxide / tetrahydrofuran; methanol / 3 h / 20 °C / Reflux

3: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C

4: tetrahydrofuran / 3.17 h / 0 - 20 °C

5: borane-THF / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere; Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; borane-THF; oxalyl dichloride; water; potassium carbonate; N,N-dimethyl-formamide; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;

Reference yield:

: C₁₃H₆ClF₃O

: 1427407-40-6
3-[[2,6-difluoro-3-(3-fluorophenyl)phenyl]methylamino]-2,4-difluorophenol

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 3.17 h / 0 - 20 °C

2: borane-THF / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere; Reflux

With borane-THF; In tetrahydrofuran;