[({5-[(1R,2R)-1,2-dihydroxy-2-(5-{[(hydroxyphosphonoyl)(4-nitrophenyl)methyl]amino}-1,3,4-thiadiazol-2-yl)ethyl]-1,3,4-thiadiazol-2-yl}amino)(4-nitrophenyl)methyl]phosphinic acid

Base Information

• Chemical Name: [({5-[(1R,2R)-1,2-dihydroxy-2-(5-{[(hydroxyphosphonoyl)(4-nitrophenyl)methyl]amino}-1,3,4-thiadiazol-2-yl)ethyl]-1,3,4-thiadiazol-2-yl}amino)(4-nitrophenyl)methyl]phosphinic acid
• CAS No.: 1381806-73-0
• Molecular Formula: C₂₀H₂₀N₈O₁₀P₂S₂
• Molecular Weight: 658.506
• Mol file: 1381806-73-0.mol

Synonyms:[({5-[(1R,2R)-1,2-dihydroxy-2-(5-{[(hydroxyphosphonoyl)(4-nitrophenyl)methyl]amino}-1,3,4-thiadiazol-2-yl)ethyl]-1,3,4-thiadiazol-2-yl}amino)(4-nitrophenyl)methyl]phosphinic acid

Chemical Property of [({5-[(1R,2R)-1,2-dihydroxy-2-(5-{[(hydroxyphosphonoyl)(4-nitrophenyl)methyl]amino}-1,3,4-thiadiazol-2-yl)ethyl]-1,3,4-thiadiazol-2-yl}amino)(4-nitrophenyl)methyl]phosphinic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [({5-[(1R,2R)-1,2-dihydroxy-2-(5-{[(hydroxyphosphonoyl)(4-nitrophenyl)methyl]amino}-1,3,4-thiadiazol-2-yl)ethyl]-1,3,4-thiadiazol-2-yl}amino)(4-nitrophenyl)methyl]phosphinic acid

There total 2 articles about [({5-[(1R,2R)-1,2-dihydroxy-2-(5-{[(hydroxyphosphonoyl)(4-nitrophenyl)methyl]amino}-1,3,4-thiadiazol-2-yl)ethyl]-1,3,4-thiadiazol-2-yl}amino)(4-nitrophenyl)methyl]phosphinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

(1R,2R)-1,2-bis(5-{[(4-nitrophenyl)methylidene]amino}-1,3,4-thiadiazol-2-yl)ethane-1,2-diol (1381806-30-9) → [({5-[(1R,2R)-1,2-dihydroxy-2-(5-{[(hydroxyphosphonoyl)(4-nitrophenyl)methyl]amino}-1,3,4-thiadiazol-2-yl)ethyl]-1,3,4-thiadiazol-2-yl}amino)(4-nitrophenyl)methyl]phosphinic acid (1381806-73-0)

Guidance literature:

(1R,2R)-1,2-bis(5-{[(4-nitrophenyl)methylidene]amino}-1,3,4-thiadiazol-2-yl)ethane-1,2-diol; With hypophosphorous acid; In acetonitrile; for 5h; Reflux;

In acetonitrile; at 20 ℃; for 24h;

DOI:10.1080/10426507.2011.636412

Reference yield:

(1R,2R)-1,2-bis(5-amino-1,3,4-thiadiazol-2-yl)ethane-1,2-diol + 4-nitrobenzaldehdye (555-16-8) → [({5-[(1R,2R)-1,2-dihydroxy-2-(5-{[(hydroxyphosphonoyl)(4-nitrophenyl)methyl]amino}-1,3,4-thiadiazol-2-yl)ethyl]-1,3,4-thiadiazol-2-yl}amino)(4-nitrophenyl)methyl]phosphinic acid (1381806-73-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sulfuric acid / ethanol; chloroform / 12 h / Reflux

2.1: hypophosphorous acid / acetonitrile / 5 h / Reflux

2.2: 24 h / 20 °C

With sulfuric acid; hypophosphorous acid; In ethanol; chloroform; acetonitrile;

DOI:10.1080/10426507.2011.636412

upstream raw materials:

4-nitrobenzaldehdye

(1R,2R)-1,2-bis(5-{[(4-nitrophenyl)methylidene]amino}-1,3,4-thiadiazol-2-yl)ethane-1,2-diol