tert-butyl 4-{4-[5-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenylaminocarbonyl)-2-methyl-phenoxy]-pyrimidin-2-yl}-piperazine-1-carboxylate

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Chemical Name:tert-butyl 4-{4-[5-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenylaminocarbonyl)-2-methyl-phenoxy]-pyrimidin-2-yl}-piperazine-1-carboxylate
CAS No.:1215030-59-3
Molecular Formula:C₃₃H₄₄N₆O₇S
Molecular Weight:668.814
Hs Code.:

tert-butyl 4-{4-[5-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenylaminocarbonyl)-2-methyl-phenoxy]-pyrimidin-2-yl}-piperazine-1-carboxylate

Synonyms:tert-butyl 4-{4-[5-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenylaminocarbonyl)-2-methyl-phenoxy]-pyrimidin-2-yl}-piperazine-1-carboxylate

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Chemical Property of tert-butyl 4-{4-[5-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenylaminocarbonyl)-2-methyl-phenoxy]-pyrimidin-2-yl}-piperazine-1-carboxylate

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Technology Process of tert-butyl 4-{4-[5-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenylaminocarbonyl)-2-methyl-phenoxy]-pyrimidin-2-yl}-piperazine-1-carboxylate

There total 5 articles about tert-butyl 4-{4-[5-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenylaminocarbonyl)-2-methyl-phenoxy]-pyrimidin-2-yl}-piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1215030-42-4
N-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenyl)-3-(2-chloro-pyrimidin-4-yloxy)-4-methyl-benzamide

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 1215030-59-3
tert-butyl 4-{4-[5-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenylaminocarbonyl)-2-methyl-phenoxy]-pyrimidin-2-yl}-piperazine-1-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; at 70 ℃; for 4h;

Reference yield:

: 1215030-28-6
3-benzyloxy-N-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenyl)-4-methyl-benzamide

: 1215030-59-3
tert-butyl 4-{4-[5-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenylaminocarbonyl)-2-methyl-phenoxy]-pyrimidin-2-yl}-piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 20 °C / 2585.81 Torr

2: potassium carbonate / N,N-dimethyl-formamide; acetonitrile / 20 °C

3: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 4 h / 70 °C

With hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 695179-07-8
N-(3-amino-5-tert-butyl-2-methoxy-phenyl)-methanesulphonamide hydrochloride

: 1215030-59-3
tert-butyl 4-{4-[5-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenylaminocarbonyl)-2-methyl-phenoxy]-pyrimidin-2-yl}-piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.25 h / 20 °C / Inert atmosphere

1.2: 50 °C

2.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 20 °C / 2585.81 Torr

3.1: potassium carbonate / N,N-dimethyl-formamide; acetonitrile / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 4 h / 70 °C

With 1-hydroxy-7-aza-benzotriazole; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide; acetonitrile;