(Z)-tert-butyl (tert-butoxycarbonylamino)(2-chloro-5-(3-(dimethylamino)propyl)phenylamino)methylenecarbamate

Base Information

Chemical Name:(Z)-tert-butyl (tert-butoxycarbonylamino)(2-chloro-5-(3-(dimethylamino)propyl)phenylamino)methylenecarbamate
CAS No.:1351438-82-8
Molecular Formula:C₂₂H₃₅ClN₄O₄
Molecular Weight:454.997
Hs Code.:

Synonyms:(Z)-tert-butyl (tert-butoxycarbonylamino)(2-chloro-5-(3-(dimethylamino)propyl)phenylamino)methylenecarbamate

Suppliers and Price of (Z)-tert-butyl (tert-butoxycarbonylamino)(2-chloro-5-(3-(dimethylamino)propyl)phenylamino)methylenecarbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (Z)-tert-butyl (tert-butoxycarbonylamino)(2-chloro-5-(3-(dimethylamino)propyl)phenylamino)methylenecarbamate

Chemical Property:

Purity/Quality:

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Technology Process of (Z)-tert-butyl (tert-butoxycarbonylamino)(2-chloro-5-(3-(dimethylamino)propyl)phenylamino)methylenecarbamate

There total 4 articles about (Z)-tert-butyl (tert-butoxycarbonylamino)(2-chloro-5-(3-(dimethylamino)propyl)phenylamino)methylenecarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1226111-72-3
2-chloro-5-[3-(dimethylamino)propyl]aniline

: 322474-21-5
N,N'-bis-Boc-S-methyl-isothiourea

: 1351438-82-8
(Z)-tert-butyl (tert-butoxycarbonylamino)(2-chloro-5-(3-(dimethylamino)propyl)phenylamino)methylenecarbamate

Guidance literature:: With mercury (II) chloride; triethylamine; In dichloromethane; at 20 ℃; Inert atmosphere;
DOI:10.1021/jm2011172

Reference yield:

: 7223-38-3
N,N-Dimethylpropargylamin

: 1351438-82-8
(Z)-tert-butyl (tert-butoxycarbonylamino)(2-chloro-5-(3-(dimethylamino)propyl)phenylamino)methylenecarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 20 °C / Inert atmosphere

1.2: 80 °C / Inert atmosphere

2.1: hydrogen / ethanol; water / 3 h / Inert atmosphere

3.1: mercury (II) chloride; triethylamine / dichloromethane / 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; hydrogen; mercury (II) chloride; triethylamine; In ethanol; dichloromethane; water; 1.1: Sonogashira coupling;
DOI:10.1021/jm2011172

Reference yield:

: 1350816-33-9
2-chloro-5-[3-(dimethylamino)prop-1-yn-1-yl]aniline

: 1351438-82-8
(Z)-tert-butyl (tert-butoxycarbonylamino)(2-chloro-5-(3-(dimethylamino)propyl)phenylamino)methylenecarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / ethanol; water / 3 h / Inert atmosphere

2: mercury (II) chloride; triethylamine / dichloromethane / 20 °C / Inert atmosphere

With hydrogen; mercury (II) chloride; triethylamine; In ethanol; dichloromethane; water;
DOI:10.1021/jm2011172