(S)-3-(Dimethoxy-phosphoryl)-6-oxo-tetrahydro-pyridazine-1,2-dicarboxylic acid bis-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl) ester

Base Information

Chemical Name:(S)-3-(Dimethoxy-phosphoryl)-6-oxo-tetrahydro-pyridazine-1,2-dicarboxylic acid bis-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl) ester
CAS No.:343326-47-6
Molecular Formula:C₂₈H₄₉N₂O₈P
Molecular Weight:572.679
Hs Code.:

Synonyms:(S)-3-(Dimethoxy-phosphoryl)-6-oxo-tetrahydro-pyridazine-1,2-dicarboxylic acid bis-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl) ester

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Chemical Property of (S)-3-(Dimethoxy-phosphoryl)-6-oxo-tetrahydro-pyridazine-1,2-dicarboxylic acid bis-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl) ester

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Technology Process of (S)-3-(Dimethoxy-phosphoryl)-6-oxo-tetrahydro-pyridazine-1,2-dicarboxylic acid bis-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl) ester

There total 3 articles about (S)-3-(Dimethoxy-phosphoryl)-6-oxo-tetrahydro-pyridazine-1,2-dicarboxylic acid bis-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 343326-43-2
(S)-3-(Dimethoxy-phosphoryl)-tetrahydro-pyridazine-1,2-dicarboxylic acid bis-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl) ester

: 343326-47-6
(S)-3-(Dimethoxy-phosphoryl)-6-oxo-tetrahydro-pyridazine-1,2-dicarboxylic acid bis-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl) ester

Guidance literature:: With sodium periodate; ruthenium tetroxide; In water; ethyl acetate;
DOI:10.1016/S0040-4039(01)00283-0

Reference yield:

: di-(-)-menthyl azodicarboxylate

: 343326-47-6
(S)-3-(Dimethoxy-phosphoryl)-6-oxo-tetrahydro-pyridazine-1,2-dicarboxylic acid bis-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl) ester

Guidance literature:: Multi-step reaction with 3 steps

1: 73 percent / TMSOTf / CH₂Cl₂ / 12 h / 20 °C

2: 65 percent / H₂ / Pd/C / methanol / 3040 Torr

3: 57 percent / RuO₄; NaIO₄ / ethyl acetate; H₂O

With sodium periodate; ruthenium tetroxide; trimethylsilyl trifluoromethanesulfonate; hydrogen; palladium on activated charcoal; In methanol; dichloromethane; water; ethyl acetate; 1: hetero Diels-Alder reaction;
DOI:10.1016/S0040-4039(01)00283-0

Reference yield:

: 343326-42-1
(3R)- and (3S)-di-(-)-menthyl 3-dimethylphosphoryl-1,2,3,6-tetrahydropyridazine-1,2-dicarboxylate

: 343326-47-6
(S)-3-(Dimethoxy-phosphoryl)-6-oxo-tetrahydro-pyridazine-1,2-dicarboxylic acid bis-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl) ester

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / H₂ / Pd/C / methanol / 3040 Torr

2: 57 percent / RuO₄; NaIO₄ / ethyl acetate; H₂O

With sodium periodate; ruthenium tetroxide; hydrogen; palladium on activated charcoal; In methanol; water; ethyl acetate;
DOI:10.1016/S0040-4039(01)00283-0