{N-[(1R,2S)-2-fluoro-1-phenyl-2-{2-[(S)-p-tolylsulfinyl]phenyl}]ethyl}-(S)-p-tolylsulfinamide

Base Information

Chemical Name:{N-[(1R,2S)-2-fluoro-1-phenyl-2-{2-[(S)-p-tolylsulfinyl]phenyl}]ethyl}-(S)-p-tolylsulfinamide
CAS No.:1311404-07-5
Molecular Formula:C₂₈H₂₆FNO₂S₂
Molecular Weight:491.65
Hs Code.:

Synonyms:{N-[(1R,2S)-2-fluoro-1-phenyl-2-{2-[(S)-p-tolylsulfinyl]phenyl}]ethyl}-(S)-p-tolylsulfinamide

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Chemical Property of {N-[(1R,2S)-2-fluoro-1-phenyl-2-{2-[(S)-p-tolylsulfinyl]phenyl}]ethyl}-(S)-p-tolylsulfinamide

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Technology Process of {N-[(1R,2S)-2-fluoro-1-phenyl-2-{2-[(S)-p-tolylsulfinyl]phenyl}]ethyl}-(S)-p-tolylsulfinamide

There total 3 articles about {N-[(1R,2S)-2-fluoro-1-phenyl-2-{2-[(S)-p-tolylsulfinyl]phenyl}]ethyl}-(S)-p-tolylsulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: C₁₅H₁₅NOS

: 1311404-00-8
1-(fluoromethyl)-2-[(S)-p-tolylsulfinyl]benzene

: 1311404-07-5
{N-[(1R,2S)-2-fluoro-1-phenyl-2-{2-[(S)-p-tolylsulfinyl]phenyl}]ethyl}-(S)-p-tolylsulfinamide

Guidance literature:: 1-(fluoromethyl)-2-[(S)-p-tolylsulfinyl]benzene; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 0.25h; Inert atmosphere;

C₁₅H₁₅NOS; In tetrahydrofuran; hexane; at -78 ℃; Inert atmosphere;

With water; In tetrahydrofuran; hexane; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1002/chem.201100455

Reference yield:

: 1311404-15-5
(S)‐2‐(p‐tolylsulfinyl)benzyl 4‐methylbenzenesulfonate

: 1311404-07-5
{N-[(1R,2S)-2-fluoro-1-phenyl-2-{2-[(S)-p-tolylsulfinyl]phenyl}]ethyl}-(S)-p-tolylsulfinamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: cesium fluoride / acetonitrile / 80 °C / Inert atmosphere; Ionic liquid

2.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 0.25 h / -78 °C / Inert atmosphere

2.2: -78 °C / Inert atmosphere

2.3: Inert atmosphere

With cesium fluoride; lithium diisopropyl amide; In tetrahydrofuran; hexane; acetonitrile;
DOI:10.1002/chem.201100455

Reference yield:

: 59153-49-0
(S)‐(2‐(p‐tolylsulfinyl)phenyl)methanol

: 1311404-07-5
{N-[(1R,2S)-2-fluoro-1-phenyl-2-{2-[(S)-p-tolylsulfinyl]phenyl}]ethyl}-(S)-p-tolylsulfinamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide / tetrahydrofuran / 5 h / 20 °C / Inert atmosphere

2.1: cesium fluoride / acetonitrile / 80 °C / Inert atmosphere; Ionic liquid

3.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 0.25 h / -78 °C / Inert atmosphere

3.2: -78 °C / Inert atmosphere

3.3: Inert atmosphere

With cesium fluoride; potassium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; hexane; acetonitrile;
DOI:10.1002/chem.201100455