(3S,5S)-3-ethynyl-5-{(R)-1-[(4-methoxybenzyl)oxy]ethyl}-1-(4-methoxyphenyl)-12,12,13,13-tetramethyl-2,6,11-trioxa-12-silatetradec-8-yne

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Chemical Name:(3S,5S)-3-ethynyl-5-{(R)-1-[(4-methoxybenzyl)oxy]ethyl}-1-(4-methoxyphenyl)-12,12,13,13-tetramethyl-2,6,11-trioxa-12-silatetradec-8-yne
CAS No.:1621135-52-1
Molecular Formula:C₃₃H₄₆O₆Si
Molecular Weight:566.81
Hs Code.:

Synonyms:(3S,5S)-3-ethynyl-5-{(R)-1-[(4-methoxybenzyl)oxy]ethyl}-1-(4-methoxyphenyl)-12,12,13,13-tetramethyl-2,6,11-trioxa-12-silatetradec-8-yne

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Chemical Property of (3S,5S)-3-ethynyl-5-{(R)-1-[(4-methoxybenzyl)oxy]ethyl}-1-(4-methoxyphenyl)-12,12,13,13-tetramethyl-2,6,11-trioxa-12-silatetradec-8-yne

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Technology Process of (3S,5S)-3-ethynyl-5-{(R)-1-[(4-methoxybenzyl)oxy]ethyl}-1-(4-methoxyphenyl)-12,12,13,13-tetramethyl-2,6,11-trioxa-12-silatetradec-8-yne

There total 4 articles about (3S,5S)-3-ethynyl-5-{(R)-1-[(4-methoxybenzyl)oxy]ethyl}-1-(4-methoxyphenyl)-12,12,13,13-tetramethyl-2,6,11-trioxa-12-silatetradec-8-yne which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1621135-47-4
(2R,3S,5S)-2,5-bis(4-methoxybenzyl)hept-6-yn-2,3,5-triol

: 219996-95-9
tert-butyl((4-iodobut-2-yn-1-yl)oxy)dimethylsilane

: 1621135-52-1
(3S,5S)-3-ethynyl-5-{(R)-1-[(4-methoxybenzyl)oxy]ethyl}-1-(4-methoxyphenyl)-12,12,13,13-tetramethyl-2,6,11-trioxa-12-silatetradec-8-yne

Guidance literature:: (2R,3S,5S)-2,5-bis(4-methoxybenzyl)hept-6-yn-2,3,5-triol; With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil; for 0.25h; Cooling with ice; Inert atmosphere;

tert-butyl((4-iodobut-2-yn-1-yl)oxy)dimethylsilane; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 6h; Inert atmosphere;
DOI:10.1002/asia.201301647

Reference yield:

: C₂₂H₂₈O₆

: 1621135-52-1
(3S,5S)-3-ethynyl-5-{(R)-1-[(4-methoxybenzyl)oxy]ethyl}-1-(4-methoxyphenyl)-12,12,13,13-tetramethyl-2,6,11-trioxa-12-silatetradec-8-yne

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / methanol; tetrahydrofuran / 15.75 h / 20 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran; mineral oil; N,N-dimethyl-formamide / 0.25 h / Cooling with ice; Inert atmosphere

2.2: 6 h / 20 °C / Inert atmosphere

With sodium hydride; potassium carbonate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; mineral oil;
DOI:10.1002/asia.201301647

Reference yield:

: 1621135-50-9
Aalyl 3,6-dideoxy-α-D-arabinohexofuranoside

: 1621135-52-1
(3S,5S)-3-ethynyl-5-{(R)-1-[(4-methoxybenzyl)oxy]ethyl}-1-(4-methoxyphenyl)-12,12,13,13-tetramethyl-2,6,11-trioxa-12-silatetradec-8-yne

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil; N,N-dimethyl-formamide / 0.08 h / Cooling with ice; Inert atmosphere

1.2: 3 h / 20 °C / Inert atmosphere

2.1: triphenylphosphine; 1,3-dimethylbarbituric acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol / 6 h / 20 °C / Inert atmosphere

3.1: potassium carbonate / methanol; tetrahydrofuran / 15.75 h / 20 °C / Inert atmosphere

4.1: sodium hydride / tetrahydrofuran; mineral oil; N,N-dimethyl-formamide / 0.25 h / Cooling with ice; Inert atmosphere

4.2: 6 h / 20 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,3-dimethylbarbituric acid; sodium hydride; potassium carbonate; triphenylphosphine; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; mineral oil;
DOI:10.1002/asia.201301647