1-[1-(4-chloro-phenyl)-cyclobutyl]-7-piperazin-1-yl-3,4-dihydro-isoquinoline

Base Information

Chemical Name:1-[1-(4-chloro-phenyl)-cyclobutyl]-7-piperazin-1-yl-3,4-dihydro-isoquinoline
CAS No.:1190643-79-8
Molecular Formula:C₂₃H₂₆ClN₃
Molecular Weight:379.933
Hs Code.:

Synonyms:1-[1-(4-chloro-phenyl)-cyclobutyl]-7-piperazin-1-yl-3,4-dihydro-isoquinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-[1-(4-chloro-phenyl)-cyclobutyl]-7-piperazin-1-yl-3,4-dihydro-isoquinoline

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Technology Process of 1-[1-(4-chloro-phenyl)-cyclobutyl]-7-piperazin-1-yl-3,4-dihydro-isoquinoline

There total 2 articles about 1-[1-(4-chloro-phenyl)-cyclobutyl]-7-piperazin-1-yl-3,4-dihydro-isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1190643-78-7
C₃₀H₃₂ClN₃O₂S

: 1190643-79-8
1-[1-(4-chloro-phenyl)-cyclobutyl]-7-piperazin-1-yl-3,4-dihydro-isoquinoline

Guidance literature:: C₃₀H₃₂ClN₃O₂S; With hydrogen bromide; In acetic acid; at 70 ℃; for 11h;

With sodium hydroxide; In water; acetic acid;

Reference yield:

: 1190643-77-6
1-[1-(4-chloro-phenyl)-cyclobutyl]-3,4-dihydro-isoquinolin-7-ylamine

: 1190643-79-8
1-[1-(4-chloro-phenyl)-cyclobutyl]-7-piperazin-1-yl-3,4-dihydro-isoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / water; acetonitrile / 3 h / 130 °C / Microwave irradiation

2: hydrogen bromide / acetic acid / 11 h / 70 °C

With hydrogen bromide; caesium carbonate; In water; acetic acid; acetonitrile;