3-(4-Cyano-phenyl)-N-phenyl-3-(toluene-4-sulfonylamino)-propionamide

Base Information

• Chemical Name: 3-(4-Cyano-phenyl)-N-phenyl-3-(toluene-4-sulfonylamino)-propionamide
• CAS No.: 80972-08-3
• Molecular Formula: C₂₃H₂₁N₃O₃S
• Molecular Weight: 419.504
• Mol file: 80972-08-3.mol

Synonyms:3-(4-Cyano-phenyl)-N-phenyl-3-(toluene-4-sulfonylamino)-propionamide

Chemical Property of 3-(4-Cyano-phenyl)-N-phenyl-3-(toluene-4-sulfonylamino)-propionamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-Cyano-phenyl)-N-phenyl-3-(toluene-4-sulfonylamino)-propionamide

There total 4 articles about 3-(4-Cyano-phenyl)-N-phenyl-3-(toluene-4-sulfonylamino)-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

3-(4-Cyano-phenyl)-3-(toluene-4-sulfonylamino)-propionyl chloride (80972-01-6) + aniline (62-53-3) → 3-(4-Cyano-phenyl)-N-phenyl-3-(toluene-4-sulfonylamino)-propionamide (80972-08-3)

Guidance literature:

In benzene; Ambient temperature;

Reference yield:

(+/-)-3-amino-3-(4-cyanophenyl)propanoic acid (80971-95-5) → 3-(4-Cyano-phenyl)-N-phenyl-3-(toluene-4-sulfonylamino)-propionamide (80972-08-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 46 percent / KOH (1mol/l) / diethyl ether / 12 h / Ambient temperature

2: SOCl₂ / 1 h / Heating

3: 53 percent / benzene / Ambient temperature

With potassium hydroxide; thionyl chloride; In diethyl ether; benzene;

Reference yield:

3-(4-Cyano-phenyl)-3-(toluene-4-sulfonylamino)-propionic acid (80971-97-7) → 3-(4-Cyano-phenyl)-N-phenyl-3-(toluene-4-sulfonylamino)-propionamide (80972-08-3)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / 1 h / Heating

2: 53 percent / benzene / Ambient temperature

With thionyl chloride; In benzene;

upstream raw materials:

3-(4-Cyano-phenyl)-3-(toluene-4-sulfonylamino)-propionyl chloride

aniline

(+/-)-3-amino-3-(4-cyanophenyl)propanoic acid

3-(4-Cyano-phenyl)-3-(toluene-4-sulfonylamino)-propionic acid

Downstream raw materials:

3-(4-Carbamimidoyl-phenyl)-N-phenyl-3-(toluene-4-sulfonylamino)-propionamide; hydriodide

4-[2-Phenylcarbamoyl-1-(toluene-4-sulfonylamino)-ethyl]-thiobenzimidic acid methyl ester; hydriodide

N-Phenyl-3-(4-thiocarbamoyl-phenyl)-3-(toluene-4-sulfonylamino)-propionamide