- Chemical Name:1-(1,3-benzothiazol-2-yl)-2,2,2-trifluoroethanone
- CAS No.:929973-34-2
- Molecular Formula:C9H4F3NOS
- Molecular Weight:231.198
- Hs Code.:
- Mol file:929973-34-2.mol
Synonyms:1-(1,3-benzothiazol-2-yl)-2,2,2-trifluoroethanone
Synonyms:1-(1,3-benzothiazol-2-yl)-2,2,2-trifluoroethanone
99% *data from raw suppliers
The research focuses on the noncatalytic electrophilic oxyalkylation of anilines with 2-trifluoroacetyl-1,3-benzothiazole, aiming to form trifluoromethyl-substituted alcohols. The study investigates the reaction's regioselectivity, which is found to be highly dependent on the structure of the aniline used. Various substituted anilines (compounds 2–18) were reacted with 2-trifluoroacetyl-1,3-benzothiazole (1a) under heating in toluene at 60–100 °C for 0.5–4 hours, yielding the desired trifluoromethyl alcohols 2a–18a in 25–99% yields. The reactions' outcomes were analyzed using 1H NMR, 13C NMR, 19F NMR, and APSI MS to determine the structures and confirm the formation of the products, with particular attention to the ortho/para-substitution patterns influenced by the meta-substituents on the aniline reactants.