tert-butyl 4-((7-(4-(methylsulfonyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)-piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-((7-(4-(methylsulfonyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)-piperidine-1-carboxylate
CAS No.:1416272-93-9
Molecular Formula:C₂₃H₂₈N₄O₅S
Molecular Weight:472.565
Hs Code.:

Synonyms:tert-butyl 4-((7-(4-(methylsulfonyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)-piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-((7-(4-(methylsulfonyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)-piperidine-1-carboxylate

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Technology Process of tert-butyl 4-((7-(4-(methylsulfonyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)-piperidine-1-carboxylate

There total 4 articles about tert-butyl 4-((7-(4-(methylsulfonyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)-piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1416272-92-8
tert-butyl 4-((7-(4-bromophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)piperidine-1-carboxylate

: 20277-69-4
sodium methansulfinate

: 1416272-93-9
tert-butyl 4-((7-(4-(methylsulfonyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)-piperidine-1-carboxylate

Guidance literature:: With copper(l) iodide; L-proline; sodium hydroxide; In dimethyl sulfoxide; at 110 ℃; for 18h; Sealed tube;
DOI:10.1021/jm301404a

Reference yield:

: 589-87-7
1,4-bromoiodobenzene

: 1416272-93-9
tert-butyl 4-((7-(4-(methylsulfonyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)-piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: copper(l) iodide; potassium phosphate; (1R,2R)-1,2-diaminocyclohexane / 15 h / 20 °C / Inert atmosphere; Reflux

2: caesium carbonate / N,N-dimethyl-formamide / 18 h / 110 °C / Inert atmosphere

3: copper(l) iodide; L-proline; sodium hydroxide / dimethyl sulfoxide / 18 h / 110 °C / Sealed tube

With potassium phosphate; copper(l) iodide; (1R,2R)-1,2-diaminocyclohexane; caesium carbonate; L-proline; sodium hydroxide; In dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm301404a

Reference yield:

: 3680-69-1
4-chloro-1H-pyrrolo[2,3-d]pyrimidine

: 1416272-93-9
tert-butyl 4-((7-(4-(methylsulfonyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)-piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: copper(l) iodide; potassium phosphate; (1R,2R)-1,2-diaminocyclohexane / 15 h / 20 °C / Inert atmosphere; Reflux

2: caesium carbonate / N,N-dimethyl-formamide / 18 h / 110 °C / Inert atmosphere

3: copper(l) iodide; L-proline; sodium hydroxide / dimethyl sulfoxide / 18 h / 110 °C / Sealed tube

With potassium phosphate; copper(l) iodide; (1R,2R)-1,2-diaminocyclohexane; caesium carbonate; L-proline; sodium hydroxide; In dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm301404a