N-(3,4-Dichloro-phenyl)-N'-(4-hydroxy-5,6,7,8-tetrahydro-quinazolin-2-yl)-guanidine

Base Information

• Chemical Name: N-(3,4-Dichloro-phenyl)-N'-(4-hydroxy-5,6,7,8-tetrahydro-quinazolin-2-yl)-guanidine
• CAS No.: 86177-03-9
• Molecular Formula: C₁₅H₁₅Cl₂N₅O
• Molecular Weight: 352.223

Synonyms:N-(3,4-Dichloro-phenyl)-N'-(4-hydroxy-5,6,7,8-tetrahydro-quinazolin-2-yl)-guanidine

Chemical Property of N-(3,4-Dichloro-phenyl)-N'-(4-hydroxy-5,6,7,8-tetrahydro-quinazolin-2-yl)-guanidine

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Technology Process of N-(3,4-Dichloro-phenyl)-N'-(4-hydroxy-5,6,7,8-tetrahydro-quinazolin-2-yl)-guanidine

There total 1 articles about N-(3,4-Dichloro-phenyl)-N'-(4-hydroxy-5,6,7,8-tetrahydro-quinazolin-2-yl)-guanidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

Sodium; 2-cyanoamino-5,6,7,8-tetrahydro-quinazolin-4-olate + m,p-dichloroaniline (95-76-1) → N-(3,4-Dichloro-phenyl)-N'-(4-hydroxy-5,6,7,8-tetrahydro-quinazolin-2-yl)-guanidine (86177-03-9)

Guidance literature:

With hydrogenchloride; 2-ethoxy-ethanol; In water; Heating;

DOI:10.1021/jm00363a010

Reference yield:

4-amino-α-diethylamino-o-cresol dihydrochloride (6297-14-9) + N-(3,4-Dichloro-phenyl)-N'-(4-hydroxy-5,6,7,8-tetrahydro-quinazolin-2-yl)-guanidine (86177-03-9) → N-(3,4-Dichloro-phenyl)-N'-[4-(3-diethylaminomethyl-4-hydroxy-phenylamino)-5,6,7,8-tetrahydro-quinazolin-2-yl]-guanidine (86177-57-3)

Guidance literature:

With sodium hydroxide; trichlorophosphate; Yield given. Multistep reaction;

DOI:10.1021/jm00363a010

Reference yield:

N-(3,4-Dichloro-phenyl)-N'-(4-hydroxy-5,6,7,8-tetrahydro-quinazolin-2-yl)-guanidine (86177-03-9) + 5-amino-N,N-diethyl-2-ethoxybenzenemethanamine dihydrochloride (42389-43-5) → N-(3,4-Dichloro-phenyl)-N'-[4-(3-diethylaminomethyl-4-ethoxy-phenylamino)-5,6,7,8-tetrahydro-quinazolin-2-yl]-guanidine (86196-52-3)

Guidance literature:

With sodium hydroxide; trichlorophosphate; Yield given. Multistep reaction;

DOI:10.1021/jm00363a010

upstream raw materials:

m,p-dichloroaniline

Downstream raw materials:

N-(3,4-Dichloro-phenyl)-N'-[4-(3-diethylaminomethyl-4-hydroxy-phenylamino)-5,6,7,8-tetrahydro-quinazolin-2-yl]-guanidine

N-(3,4-Dichloro-phenyl)-N'-[4-(3-ethylaminomethyl-4-methoxy-phenylamino)-5,6,7,8-tetrahydro-quinazolin-2-yl]-guanidine; hydrochloride

N-(3,4-Dichloro-phenyl)-N'-[4-(3-diethylaminomethyl-4-ethoxy-phenylamino)-5,6,7,8-tetrahydro-quinazolin-2-yl]-guanidine

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