diisopropyl (2R)-2-(2-(1H-indol-3-yl)-2-(4-methoxyphenyl)ethyl)malonate

Base Information

Chemical Name:diisopropyl (2R)-2-(2-(1H-indol-3-yl)-2-(4-methoxyphenyl)ethyl)malonate
CAS No.:1432791-88-2
Molecular Formula:C₂₆H₃₁NO₅
Molecular Weight:437.536
Hs Code.:

Synonyms:diisopropyl (2R)-2-(2-(1H-indol-3-yl)-2-(4-methoxyphenyl)ethyl)malonate

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Chemical Property of diisopropyl (2R)-2-(2-(1H-indol-3-yl)-2-(4-methoxyphenyl)ethyl)malonate

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Technology Process of diisopropyl (2R)-2-(2-(1H-indol-3-yl)-2-(4-methoxyphenyl)ethyl)malonate

There total 3 articles about diisopropyl (2R)-2-(2-(1H-indol-3-yl)-2-(4-methoxyphenyl)ethyl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1432791-60-0
C₃₂H₄₅NO₅Si

: 1432791-88-2
diisopropyl (2R)-2-(2-(1H-indol-3-yl)-2-(4-methoxyphenyl)ethyl)malonate

: C₂₆H₃₁NO₅

Guidance literature:: With hydrogenchloride; In methanol; at 20 ℃; for 2h; Overall yield = 72 %; Overall yield = 36.8 mg; Inert atmosphere;
DOI:10.1021/ol4010646

Reference yield:

: 120-72-9
indole

: 1432791-88-2
diisopropyl (2R)-2-(2-(1H-indol-3-yl)-2-(4-methoxyphenyl)ethyl)malonate

: C₂₆H₃₁NO₅

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 1.25 h / 0 - 20 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: scandium tris(trifluoromethanesulfonate) / 1,2-dichloro-ethane / 20 °C / Inert atmosphere; Molecular sieve; Glovebox

3.1: hydrogenchloride / methanol / 2 h / 20 °C / Inert atmosphere

With hydrogenchloride; sodium hydride; scandium tris(trifluoromethanesulfonate); In tetrahydrofuran; methanol; 1,2-dichloro-ethane;
DOI:10.1021/ol4010646

Reference yield:

: 40899-73-8
N-tert-butyldimethylsilylindole

: 1432791-88-2
diisopropyl (2R)-2-(2-(1H-indol-3-yl)-2-(4-methoxyphenyl)ethyl)malonate

: C₂₆H₃₁NO₅

Guidance literature:: Multi-step reaction with 2 steps

1: scandium tris(trifluoromethanesulfonate) / 1,2-dichloro-ethane / 20 °C / Inert atmosphere; Molecular sieve; Glovebox

2: hydrogenchloride / methanol / 2 h / 20 °C / Inert atmosphere

With hydrogenchloride; scandium tris(trifluoromethanesulfonate); In methanol; 1,2-dichloro-ethane;
DOI:10.1021/ol4010646