Technology Process of 2',3',5'-tri-O-acetyl-O4-2-<(4-cyanophenyl)ethyl>ribosylthymine
There total 7 articles about 2',3',5'-tri-O-acetyl-O4-2-<(4-cyanophenyl)ethyl>ribosylthymine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
1,4-diaza-bicyclo[2.2.2]octane; triethylamine;
In
dichloromethane;
for 24h;
Ambient temperature;
DOI:10.1002/hlca.19950780706
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 95 percent / SnCl4 / 1,2-dichloro-ethane / 20 h / Ambient temperature
2: 93 percent / 0.018 M NaOMe / methanol / 0.5 h / Heating
3: 94 percent / pyridine / 10 h / Ambient temperature
4: 76 percent / Et3N, DMAP / CH2Cl2 / 4 h / Ambient temperature
5: 58 percent / Et3N, DABCO / CH2Cl2 / 24 h / Ambient temperature
With
pyridine; 1,4-diaza-bicyclo[2.2.2]octane; dmap; sodium methylate; tin(IV) chloride; triethylamine;
In
methanol; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1002/hlca.19950780706
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 93 percent / 0.018 M NaOMe / methanol / 0.5 h / Heating
2: 94 percent / pyridine / 10 h / Ambient temperature
3: 76 percent / Et3N, DMAP / CH2Cl2 / 4 h / Ambient temperature
4: 58 percent / Et3N, DABCO / CH2Cl2 / 24 h / Ambient temperature
With
pyridine; 1,4-diaza-bicyclo[2.2.2]octane; dmap; sodium methylate; triethylamine;
In
methanol; dichloromethane;
DOI:10.1002/hlca.19950780706
