5-[(2S)-2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]propyl]-N-[4-fluoro-3-(trifluoromethyl)phenyl]-1-(2-methyl-4-pyridinyl)-1H-1,2,4-triazol-3-amine

Base Information

• Chemical Name: 5-[(2S)-2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]propyl]-N-[4-fluoro-3-(trifluoromethyl)phenyl]-1-(2-methyl-4-pyridinyl)-1H-1,2,4-triazol-3-amine
• CAS No.: 1187853-27-5
• Molecular Formula: C₃₄H₃₅F₄N₅OSi
• Molecular Weight: 633.764

Synonyms:5-[(2S)-2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]propyl]-N-[4-fluoro-3-(trifluoromethyl)phenyl]-1-(2-methyl-4-pyridinyl)-1H-1,2,4-triazol-3-amine

Chemical Property of 5-[(2S)-2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]propyl]-N-[4-fluoro-3-(trifluoromethyl)phenyl]-1-(2-methyl-4-pyridinyl)-1H-1,2,4-triazol-3-amine

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Technology Process of 5-[(2S)-2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]propyl]-N-[4-fluoro-3-(trifluoromethyl)phenyl]-1-(2-methyl-4-pyridinyl)-1H-1,2,4-triazol-3-amine

There total 1 articles about 5-[(2S)-2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]propyl]-N-[4-fluoro-3-(trifluoromethyl)phenyl]-1-(2-methyl-4-pyridinyl)-1H-1,2,4-triazol-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-[(3S)-3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-oxobutyl]-N'-[4-fluoro-3-(trifluoromethyl)phenyl]-carbamimidothioic acid methyl ester (1187853-20-8) + 2-(methylpyridin-4-yl)hydrazine (100518-39-6) → 5-[(2S)-2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]propyl]-N-[4-fluoro-3-(trifluoromethyl)phenyl]-1-(2-methyl-4-pyridinyl)-1H-1,2,4-triazol-3-amine (1187853-27-5)

Guidance literature:

With mercury dichloride; In N,N-dimethyl-formamide; at 20 - 80 ℃;

Reference yield: 13.9%

5-[(2S)-2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]propyl]-N-[4-fluoro-3-(trifluoromethyl)phenyl]-1-(2-methyl-4-pyridinyl)-1H-1,2,4-triazol-3-amine (1187853-27-5) → 3-[[4-fluoro-3-(trifluoromethyl)phenyl]amino]-alpha-methyl-1-(2-methyl-4-pyridinyl)-(alphaS)-1H-1,2,4-triazole-5-ethanol (1187853-46-8)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 2.91667h; Cooling with ice;

upstream raw materials:

N-[(3S)-3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-oxobutyl]-N'-[4-fluoro-3-(trifluoromethyl)phenyl]-carbamimidothioic acid methyl ester

2-(methylpyridin-4-yl)hydrazine

Downstream raw materials:

3-[[4-fluoro-3-(trifluoromethyl)phenyl]amino]-alpha-methyl-1-(2-methyl-4-pyridinyl)-(alphaS)-1H-1,2,4-triazole-5-ethanol

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