Technology Process of 4-(2-naphthyl)phenyl hydroxamic acid
There total 4 articles about 4-(2-naphthyl)phenyl hydroxamic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) a) tert-butyllithium, zinc chloride, b) diisobutylammonium hydride, palladium bis(triphenylphosphine) dichloride / tetrahydrofuran / 1 h / -78 - 20 °C
2: LiOH / propan-2-ol; H2O
3: 1.) DMF, (COCl)2, 2.) hydroxylamine hydrochloride, Et3N / 1.) CH2Cl2, 0 deg C, 40 min, 2.) CH2Cl2, THF, H2O, 30 min
With
lithium hydroxide; bis(triphenylphosphine)palladium(II) dichloride; oxalyl dichloride; Diisobutylammonium hydride; hydroxylamine hydrochloride; tert.-butyl lithium; triethylamine; N,N-dimethyl-formamide; zinc(II) chloride;
In
tetrahydrofuran; water; isopropyl alcohol;
DOI:10.1021/jm00386a022
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) a) tert-butyllithium, zinc chloride, b) diisobutylammonium hydride, palladium bis(triphenylphosphine) dichloride / tetrahydrofuran / 1 h / -78 - 20 °C
2: LiOH / propan-2-ol; H2O
3: 1.) DMF, (COCl)2, 2.) hydroxylamine hydrochloride, Et3N / 1.) CH2Cl2, 0 deg C, 40 min, 2.) CH2Cl2, THF, H2O, 30 min
With
lithium hydroxide; bis(triphenylphosphine)palladium(II) dichloride; oxalyl dichloride; Diisobutylammonium hydride; hydroxylamine hydrochloride; tert.-butyl lithium; triethylamine; N,N-dimethyl-formamide; zinc(II) chloride;
In
tetrahydrofuran; water; isopropyl alcohol;
DOI:10.1021/jm00386a022
- Guidance literature:
-
Multi-step reaction with 2 steps
1: LiOH / propan-2-ol; H2O
2: 1.) DMF, (COCl)2, 2.) hydroxylamine hydrochloride, Et3N / 1.) CH2Cl2, 0 deg C, 40 min, 2.) CH2Cl2, THF, H2O, 30 min
With
lithium hydroxide; oxalyl dichloride; hydroxylamine hydrochloride; triethylamine; N,N-dimethyl-formamide;
In
water; isopropyl alcohol;
DOI:10.1021/jm00386a022
