2-[5-(2-aminopyrimidin-5-yl)-1-tert-butyl-1H-benzimidazol-2-yl]-4-fluorobenzonitrile

Base Information

Chemical Name:2-[5-(2-aminopyrimidin-5-yl)-1-tert-butyl-1H-benzimidazol-2-yl]-4-fluorobenzonitrile
CAS No.:1310532-29-6
Molecular Formula:C₂₂H₁₉FN₆
Molecular Weight:386.431
Hs Code.:

Synonyms:2-[5-(2-aminopyrimidin-5-yl)-1-tert-butyl-1H-benzimidazol-2-yl]-4-fluorobenzonitrile

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Chemical Property of 2-[5-(2-aminopyrimidin-5-yl)-1-tert-butyl-1H-benzimidazol-2-yl]-4-fluorobenzonitrile

Chemical Property:

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Technology Process of 2-[5-(2-aminopyrimidin-5-yl)-1-tert-butyl-1H-benzimidazol-2-yl]-4-fluorobenzonitrile

There total 5 articles about 2-[5-(2-aminopyrimidin-5-yl)-1-tert-butyl-1H-benzimidazol-2-yl]-4-fluorobenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 894779-76-1
4-fluoro-2-formylbenzonitrile

: 1310531-65-7
4-(2-amino-pyrimidin-5-yl)-N₁-tert-butyl-benzene-1,2-diamine

: 1310532-29-6
2-[5-(2-aminopyrimidin-5-yl)-1-tert-butyl-1H-benzimidazol-2-yl]-4-fluorobenzonitrile

Guidance literature:: With Oxone; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

: 364-73-8
4-Bromo-1-fluoro-2-nitrobenzene

: 1310532-29-6
2-[5-(2-aminopyrimidin-5-yl)-1-tert-butyl-1H-benzimidazol-2-yl]-4-fluorobenzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / 16 h / 60 °C

2: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 20 - 100 °C

3: zinc; ammonium formate / ethanol / 2 h / 50 °C

4: Oxone / N,N-dimethyl-formamide / 2 h / 20 °C

With Oxone; ammonium formate; potassium carbonate; zinc; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1135351-95-9
4-bromo-N-(tert-butyl)-2-nitroaniline

: 1310532-29-6
2-[5-(2-aminopyrimidin-5-yl)-1-tert-butyl-1H-benzimidazol-2-yl]-4-fluorobenzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 20 - 100 °C

2: zinc; ammonium formate / ethanol / 2 h / 50 °C

3: Oxone / N,N-dimethyl-formamide / 2 h / 20 °C

With Oxone; ammonium formate; potassium carbonate; zinc; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; N,N-dimethyl-formamide;