(±)-2-cyclohexyl-1-(prop-2-yn-1-yl)-4-(2,2,2-trifluoro-1-methoxyethyl)-1H-imidazole

Base Information

Chemical Name:(±)-2-cyclohexyl-1-(prop-2-yn-1-yl)-4-(2,2,2-trifluoro-1-methoxyethyl)-1H-imidazole
CAS No.:1452818-87-9
Molecular Formula:C₁₅H₁₉F₃N₂O
Molecular Weight:300.324
Hs Code.:

Synonyms:(±)-2-cyclohexyl-1-(prop-2-yn-1-yl)-4-(2,2,2-trifluoro-1-methoxyethyl)-1H-imidazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (±)-2-cyclohexyl-1-(prop-2-yn-1-yl)-4-(2,2,2-trifluoro-1-methoxyethyl)-1H-imidazole

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Technology Process of (±)-2-cyclohexyl-1-(prop-2-yn-1-yl)-4-(2,2,2-trifluoro-1-methoxyethyl)-1H-imidazole

There total 7 articles about (±)-2-cyclohexyl-1-(prop-2-yn-1-yl)-4-(2,2,2-trifluoro-1-methoxyethyl)-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 1452818-85-7
(±)-2-cyclohexyl-4-(2,2,2-trifluoro-1-methoxyethyl)-1H-imidazole

: 107-19-7
propargyl alcohol

: 1452818-87-9
(±)-2-cyclohexyl-1-(prop-2-yn-1-yl)-4-(2,2,2-trifluoro-1-methoxyethyl)-1H-imidazole

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 0 - 25 ℃; for 8.5h; Inert atmosphere;
DOI:10.1002/ejoc.201201467

Reference yield:

: 1452818-82-4
(±)-2-cyclohexyl-N,N-dimethyl-5-(2,2,2-trifluoro-1-methoxyethyl)-1H-imidazole-1-sulfonamide

: 1452818-87-9
(±)-2-cyclohexyl-1-(prop-2-yn-1-yl)-4-(2,2,2-trifluoro-1-methoxyethyl)-1H-imidazole

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / water / 7 h / 25 °C / Inert atmosphere

2: caesium carbonate / N,N-dimethyl-formamide / 8.5 h / 0 - 25 °C / Inert atmosphere

With hydrogenchloride; caesium carbonate; In water; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.201201467

Reference yield:

: 2043-61-0
cyclohexanecarbaldehyde

: 1452818-87-9
(±)-2-cyclohexyl-1-(prop-2-yn-1-yl)-4-(2,2,2-trifluoro-1-methoxyethyl)-1H-imidazole

Guidance literature:: Multi-step reaction with 7 steps

1.1: ammonium bicarbonate / water / 18 h / 25 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 14 h / 25 °C / Inert atmosphere

3.1: n-butyllithium / tetrahydrofuran; hexane / 1.42 h / -78 °C / Inert atmosphere

3.2: 3 h / -78 - 25 °C / Inert atmosphere

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 25 °C / Inert atmosphere

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 0 - 25 °C / Inert atmosphere

5.2: 16 h / 25 °C / Inert atmosphere

6.1: hydrogenchloride / water / 7 h / 25 °C / Inert atmosphere

7.1: caesium carbonate / N,N-dimethyl-formamide / 8.5 h / 0 - 25 °C / Inert atmosphere

With hydrogenchloride; n-butyllithium; tetrabutyl ammonium fluoride; sodium hydride; ammonium bicarbonate; caesium carbonate; triethylamine; In tetrahydrofuran; hexane; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1002/ejoc.201201467