2-allyl-2-benzenesulfonyl-pent-4-enoic ethyl ester

Base Information

• Chemical Name: 2-allyl-2-benzenesulfonyl-pent-4-enoic ethyl ester
• CAS No.: 1332646-32-8
• Molecular Formula: C₁₆H₂₀O₄S
• Molecular Weight: 308.398
• Mol file: 1332646-32-8.mol

Synonyms:2-allyl-2-benzenesulfonyl-pent-4-enoic ethyl ester

Chemical Property of 2-allyl-2-benzenesulfonyl-pent-4-enoic ethyl ester

Chemical Property:

Purity/Quality:

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Technology Process of 2-allyl-2-benzenesulfonyl-pent-4-enoic ethyl ester

There total 1 articles about 2-allyl-2-benzenesulfonyl-pent-4-enoic ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

ethyl 2-phenylsulfonylacetate (7605-30-3) + allyl bromide (106-95-6) → 2-allyl-2-benzenesulfonyl-pent-4-enoic ethyl ester (1332646-32-8)

Guidance literature:

ethyl 2-phenylsulfonylacetate; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; Inert atmosphere; Cooling with ice;

allyl bromide; In N,N-dimethyl-formamide; mineral oil; at 20 - 50 ℃; Inert atmosphere;

DOI:10.1002/adsc.201100053

Reference yield: 99.0%

2-allyl-2-benzenesulfonyl-pent-4-enoic ethyl ester (1332646-32-8) → 1-benzenesulfonyl-cyclopent-3-enecarboxylic ethyl ester (1322546-74-6)

Guidance literature:

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane; at 40 ℃; for 1h; Solvent; Inert atmosphere;

DOI:10.1039/c4ob02480j

Reference yield: 97.0%

2-allyl-2-benzenesulfonyl-pent-4-enoic ethyl ester (1332646-32-8) → ethyl 1-(phenylsulfonyl)cyclopentanecarboxylate (140244-14-0)

Guidance literature:

2-allyl-2-benzenesulfonyl-pent-4-enoic ethyl ester; With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In tetrahydrofuran; at 40 ℃; for 0.5h; Inert atmosphere;

With formic acid; sodium hydride; In tetrahydrofuran; at 80 ℃; for 20h; Inert atmosphere;

DOI:10.1021/acs.joc.7b02468

upstream raw materials:

ethyl 2-phenylsulfonylacetate

allyl bromide

Downstream raw materials:

1-benzenesulfonyl-cyclopent-3-enecarboxylic ethyl ester

ethyl 1-(phenylsulfonyl)cyclopentanecarboxylate