methyl 1-methyl-5-(4-(1-methyl-5-((((R)-1-phenylethoxy)carbonyl)amino)-1H-pyrazol-4-yl)phenyl)-2,3-dihydro-1H-indene-1-carboxylate

Base Information

Chemical Name:methyl 1-methyl-5-(4-(1-methyl-5-((((R)-1-phenylethoxy)carbonyl)amino)-1H-pyrazol-4-yl)phenyl)-2,3-dihydro-1H-indene-1-carboxylate
CAS No.:1402466-08-3
Molecular Formula:C₃₁H₃₁N₃O₄
Molecular Weight:509.605
Hs Code.:

Synonyms:methyl 1-methyl-5-(4-(1-methyl-5-((((R)-1-phenylethoxy)carbonyl)amino)-1H-pyrazol-4-yl)phenyl)-2,3-dihydro-1H-indene-1-carboxylate

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Chemical Property of methyl 1-methyl-5-(4-(1-methyl-5-((((R)-1-phenylethoxy)carbonyl)amino)-1H-pyrazol-4-yl)phenyl)-2,3-dihydro-1H-indene-1-carboxylate

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Technology Process of methyl 1-methyl-5-(4-(1-methyl-5-((((R)-1-phenylethoxy)carbonyl)amino)-1H-pyrazol-4-yl)phenyl)-2,3-dihydro-1H-indene-1-carboxylate

There total 7 articles about methyl 1-methyl-5-(4-(1-methyl-5-((((R)-1-phenylethoxy)carbonyl)amino)-1H-pyrazol-4-yl)phenyl)-2,3-dihydro-1H-indene-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1132943-97-5
(rac)-5-bromo-1-methylindan-1-carboxylic acid methyl ester

: 1402465-79-5
(R)-1-phenylethyl 1-methyl-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1H-pyrazol-5-ylcarbamate

: 1402466-08-3
methyl 1-methyl-5-(4-(1-methyl-5-((((R)-1-phenylethoxy)carbonyl)amino)-1H-pyrazol-4-yl)phenyl)-2,3-dihydro-1H-indene-1-carboxylate

Guidance literature:: (rac)-5-bromo-1-methylindan-1-carboxylic acid methyl ester; (R)-1-phenylethyl 1-methyl-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1H-pyrazol-5-ylcarbamate; With caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; at 90 ℃; for 16h;

With hydrogenchloride; In 1,4-dioxane; water; pH=3 - 4;

Reference yield:

: 16532-79-9
4-Bromophenylacetonitrile

: 1402466-08-3
methyl 1-methyl-5-(4-(1-methyl-5-((((R)-1-phenylethoxy)carbonyl)amino)-1H-pyrazol-4-yl)phenyl)-2,3-dihydro-1H-indene-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: ethanol / 48 h / 20 °C

2.1: 144 h / -20 - 20 °C

3.1: potassium acetate / tricyclohexylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / 1,4-dioxane / 16 h / Reflux

4.1: pyridine / dichloromethane / 0.17 h / 0 - 20 °C

4.2: 16 h / 0 - 20 °C

5.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 16 h / 90 °C

5.2: pH 3 - 4

With pyridine; potassium acetate; caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; bis(dibenzylideneacetone)-palladium⁽⁰⁾; tricyclohexylphosphine; In 1,4-dioxane; ethanol; dichloromethane; water;

Reference yield:

: 112933-48-9
methyl 5-bromo-2,3-dihydro-1H-indene-1-carboxylate

: 1402466-08-3
methyl 1-methyl-5-(4-(1-methyl-5-((((R)-1-phenylethoxy)carbonyl)amino)-1H-pyrazol-4-yl)phenyl)-2,3-dihydro-1H-indene-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.75 h / -78 °C

1.2: 3 h / 20 °C

2.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 16 h / 90 °C

2.2: pH 3 - 4

With caesium carbonate; lithium hexamethyldisilazane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; water;