trans-5-(2-(4-p-tolyl-1,2,3,3a,4,8b-hexahydrocyclopenta[b]indol-7-yl)vinyl)thiophene-2-carbaldehyde

Base Information

Chemical Name:trans-5-(2-(4-p-tolyl-1,2,3,3a,4,8b-hexahydrocyclopenta[b]indol-7-yl)vinyl)thiophene-2-carbaldehyde
CAS No.:1309956-57-7
Molecular Formula:C₂₅H₂₃NOS
Molecular Weight:385.53
Hs Code.:

Synonyms:trans-5-(2-(4-p-tolyl-1,2,3,3a,4,8b-hexahydrocyclopenta[b]indol-7-yl)vinyl)thiophene-2-carbaldehyde

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Chemical Property of trans-5-(2-(4-p-tolyl-1,2,3,3a,4,8b-hexahydrocyclopenta[b]indol-7-yl)vinyl)thiophene-2-carbaldehyde

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Technology Process of trans-5-(2-(4-p-tolyl-1,2,3,3a,4,8b-hexahydrocyclopenta[b]indol-7-yl)vinyl)thiophene-2-carbaldehyde

There total 3 articles about trans-5-(2-(4-p-tolyl-1,2,3,3a,4,8b-hexahydrocyclopenta[b]indol-7-yl)vinyl)thiophene-2-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7-(2-(thiophen-2-yl)vinyl)-4-p-tolyl-1,2,3,3a,4,8b-hexahydrocyclopenta[b]indole

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 1309956-57-7
trans-5-(2-(4-p-tolyl-1,2,3,3a,4,8b-hexahydrocyclopenta[b]indol-7-yl)vinyl)thiophene-2-carbaldehyde

Guidance literature:: 7-(2-(thiophen-2-yl)vinyl)-4-p-tolyl-1,2,3,3a,4,8b-hexahydrocyclopenta[b]indole; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 0 ℃; for 1.58333h; Inert atmosphere;

N,N-dimethyl-formamide; In tetrahydrofuran; hexane; at -78 - 20 ℃; Inert atmosphere;
DOI:10.1039/c1cp20484j

Reference yield:

: 23259-98-5
2-thienylmethyltriphenylphosphonium bromide

: 1309956-57-7
trans-5-(2-(4-p-tolyl-1,2,3,3a,4,8b-hexahydrocyclopenta[b]indol-7-yl)vinyl)thiophene-2-carbaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

1.2: 48 h / 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 1.58 h / -78 - 0 °C / Inert atmosphere

2.2: -78 - 20 °C / Inert atmosphere

With n-butyllithium; sodium hydride; In tetrahydrofuran; hexane;
DOI:10.1039/c1cp20484j

Reference yield:

: 273220-35-2
4-(p-tolyl)-1,2,3,3a,4,8b-hexahydrocyclopenta[b]indole-7-carbaldehyde

: 1309956-57-7
trans-5-(2-(4-p-tolyl-1,2,3,3a,4,8b-hexahydrocyclopenta[b]indol-7-yl)vinyl)thiophene-2-carbaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

1.2: 48 h / 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 1.58 h / -78 - 0 °C / Inert atmosphere

2.2: -78 - 20 °C / Inert atmosphere

With n-butyllithium; sodium hydride; In tetrahydrofuran; hexane;
DOI:10.1039/c1cp20484j