N-(5-methyl-3-isoxazolyl)-N'-[4-(2-[2-methyl-6-(4-methylpiperazino)-4-pyrimidinyl]amino-1,3-thiazol-5-yl)phenyl]urea

Base Information

Chemical Name:N-(5-methyl-3-isoxazolyl)-N'-[4-(2-[2-methyl-6-(4-methylpiperazino)-4-pyrimidinyl]amino-1,3-thiazol-5-yl)phenyl]urea
CAS No.:1395051-12-3
Molecular Formula:C₂₄H₂₇N₉O₂S
Molecular Weight:505.603
Hs Code.:

Synonyms:N-(5-methyl-3-isoxazolyl)-N'-[4-(2-[2-methyl-6-(4-methylpiperazino)-4-pyrimidinyl]amino-1,3-thiazol-5-yl)phenyl]urea

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Chemical Property of N-(5-methyl-3-isoxazolyl)-N'-[4-(2-[2-methyl-6-(4-methylpiperazino)-4-pyrimidinyl]amino-1,3-thiazol-5-yl)phenyl]urea

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Technology Process of N-(5-methyl-3-isoxazolyl)-N'-[4-(2-[2-methyl-6-(4-methylpiperazino)-4-pyrimidinyl]amino-1,3-thiazol-5-yl)phenyl]urea

There total 4 articles about N-(5-methyl-3-isoxazolyl)-N'-[4-(2-[2-methyl-6-(4-methylpiperazino)-4-pyrimidinyl]amino-1,3-thiazol-5-yl)phenyl]urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1035700-05-0
(5-methylisoxazol-3-yl)carbamic acid 4-nitro-phenyl ester

: C₁₉H₂₃N₇S

: 1395051-12-3
N-(5-methyl-3-isoxazolyl)-N'-[4-(2-[2-methyl-6-(4-methylpiperazino)-4-pyrimidinyl]amino-1,3-thiazol-5-yl)phenyl]urea

Guidance literature:: With pyridine; at 20 ℃; for 2h;
DOI:10.1016/j.ejmech.2015.05.008

Reference yield:

: 90349-87-4
5-(4-aminophenyl)-2-amino-1,3-thiazole

: 1395051-12-3
N-(5-methyl-3-isoxazolyl)-N'-[4-(2-[2-methyl-6-(4-methylpiperazino)-4-pyrimidinyl]amino-1,3-thiazol-5-yl)phenyl]urea

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / tetrahydrofuran; mineral oil / 4 h / 0 - 20 °C

2: pyridine / 2 h / 80 °C

3: pyridine / 2 h / 20 °C

With pyridine; sodium hydride; In tetrahydrofuran; mineral oil;
DOI:10.1016/j.ejmech.2015.05.008

Reference yield:

: 1780-26-3
2,4-dichloro-2-methylpyrimidine

: 1395051-12-3
N-(5-methyl-3-isoxazolyl)-N'-[4-(2-[2-methyl-6-(4-methylpiperazino)-4-pyrimidinyl]amino-1,3-thiazol-5-yl)phenyl]urea

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / tetrahydrofuran; mineral oil / 4 h / 0 - 20 °C

2: pyridine / 2 h / 80 °C

3: pyridine / 2 h / 20 °C

With pyridine; sodium hydride; In tetrahydrofuran; mineral oil;
DOI:10.1016/j.ejmech.2015.05.008