(1S)-3-((2S,3R)-2-(4-{4-(acetyloxy)-3-[(acetyloxy)methyl]-3-hydroxybutyl}phenyl)-4-oxo-1-{4-[2-(1H-1,2,4-triazol-5-yl)ethyl]phenyl}azetidin-3-yl)-1-(4-fluorophenyl)propyl acetate

Base Information

Chemical Name:(1S)-3-((2S,3R)-2-(4-{4-(acetyloxy)-3-[(acetyloxy)methyl]-3-hydroxybutyl}phenyl)-4-oxo-1-{4-[2-(1H-1,2,4-triazol-5-yl)ethyl]phenyl}azetidin-3-yl)-1-(4-fluorophenyl)propyl acetate
CAS No.:1025468-59-0
Molecular Formula:C₃₉H₄₃FN₄O₈
Molecular Weight:714.791
Hs Code.:

(1S)-3-((2S,3R)-2-(4-{4-(acetyloxy)-3-[(acetyloxy)methyl]-3-hydroxybutyl}phenyl)-4-oxo-1-{4-[2-(1H-1,2,4-triazol-5-yl)ethyl]phenyl}azetidin-3-yl)-1-(4-fluorophenyl)propyl acetate

Synonyms:(1S)-3-((2S,3R)-2-(4-{4-(acetyloxy)-3-[(acetyloxy)methyl]-3-hydroxybutyl}phenyl)-4-oxo-1-{4-[2-(1H-1,2,4-triazol-5-yl)ethyl]phenyl}azetidin-3-yl)-1-(4-fluorophenyl)propyl acetate

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Chemical Property of (1S)-3-((2S,3R)-2-(4-{4-(acetyloxy)-3-[(acetyloxy)methyl]-3-hydroxybutyl}phenyl)-4-oxo-1-{4-[2-(1H-1,2,4-triazol-5-yl)ethyl]phenyl}azetidin-3-yl)-1-(4-fluorophenyl)propyl acetate

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Technology Process of (1S)-3-((2S,3R)-2-(4-{4-(acetyloxy)-3-[(acetyloxy)methyl]-3-hydroxybutyl}phenyl)-4-oxo-1-{4-[2-(1H-1,2,4-triazol-5-yl)ethyl]phenyl}azetidin-3-yl)-1-(4-fluorophenyl)propyl acetate

There total 1 articles about (1S)-3-((2S,3R)-2-(4-{4-(acetyloxy)-3-[(acetyloxy)methyl]-3-hydroxybutyl}phenyl)-4-oxo-1-{4-[2-(1H-1,2,4-triazol-5-yl)ethyl]phenyl}azetidin-3-yl)-1-(4-fluorophenyl)propyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1025468-58-9
(1S)-3-{(2S,3R)-2-(4-{4-(acetyloxy)-3-[(acetyloxy)methyl]-3-hydroxybut-1-yn-1-yl}phenyl)-4-oxo-1-[4-(1H-1,2,4-triazol-5-ylethynyl)phenyl]azetidin-3-yl}-1-(4-fluorophenyl)propyl acetate

: 1025468-59-0
(1S)-3-((2S,3R)-2-(4-{4-(acetyloxy)-3-[(acetyloxy)methyl]-3-hydroxybutyl}phenyl)-4-oxo-1-{4-[2-(1H-1,2,4-triazol-5-yl)ethyl]phenyl}azetidin-3-yl)-1-(4-fluorophenyl)propyl acetate

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethanol; ethyl acetate; at 20 ℃; for 16h;

Reference yield:

: 1025468-59-0
(1S)-3-((2S,3R)-2-(4-{4-(acetyloxy)-3-[(acetyloxy)methyl]-3-hydroxybutyl}phenyl)-4-oxo-1-{4-[2-(1H-1,2,4-triazol-5-yl)ethyl]phenyl}azetidin-3-yl)-1-(4-fluorophenyl)propyl acetate

: 1025467-40-6
(2S,3R)-4-{4-[3,4-dihydroxy-3-(hydroxymethyl)butyl]phenyl}-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-1-{4-[2-(1H-1,2,4-triazol-5-yl)ethyl]phenyl}azetidin-2-one

Guidance literature:: (1S)-3-((2S,3R)-2-(4-{4-(acetyloxy)-3-[(acetyloxy)methyl]-3-hydroxybutyl}phenyl)-4-oxo-1-{4-[2-(1H-1,2,4-triazol-5-yl)ethyl]phenyl}azetidin-3-yl)-1-(4-fluorophenyl)propyl acetate; With potassium trimethylsilonate; In ethanol; at 20 ℃; for 2h;

With hydrogenchloride; In ethanol; water; pH=5 - 6;