pyridin-2-yl{2-[4-(trifluoromethyl)phenyl]-5,8-dioxaspiro[3.4]oct-2-yl}-methanol

Base Information

Chemical Name:pyridin-2-yl{2-[4-(trifluoromethyl)phenyl]-5,8-dioxaspiro[3.4]oct-2-yl}-methanol
CAS No.:1432049-32-5
Molecular Formula:C₁₉H₁₈F₃NO₃
Molecular Weight:365.352
Hs Code.:

Synonyms:pyridin-2-yl{2-[4-(trifluoromethyl)phenyl]-5,8-dioxaspiro[3.4]oct-2-yl}-methanol

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Chemical Property of pyridin-2-yl{2-[4-(trifluoromethyl)phenyl]-5,8-dioxaspiro[3.4]oct-2-yl}-methanol

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Technology Process of pyridin-2-yl{2-[4-(trifluoromethyl)phenyl]-5,8-dioxaspiro[3.4]oct-2-yl}-methanol

There total 8 articles about pyridin-2-yl{2-[4-(trifluoromethyl)phenyl]-5,8-dioxaspiro[3.4]oct-2-yl}-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 20249-16-5
3-oxo-cyclobutanecarbonitrile

: 1432049-32-5
pyridin-2-yl{2-[4-(trifluoromethyl)phenyl]-5,8-dioxaspiro[3.4]oct-2-yl}-methanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene-4-sulfonic acid / toluene / 2 h / 20 °C / Reflux

2.1: potassium hexamethylsilazane / toluene / 24 h / 60 °C

3.1: n-butyllithium / hexane; diethyl ether / 0.75 h / -70 °C

3.2: 2.5 h / -70 - 20 °C

4.1: methanol; sodium tetrahydroborate / dichloromethane / 2.5 h / 20 °C

With methanol; sodium tetrahydroborate; n-butyllithium; potassium hexamethylsilazane; toluene-4-sulfonic acid; In diethyl ether; hexane; dichloromethane; toluene;

Reference yield:

: 15760-35-7
3-methylenecyclobutanecarbonitrile

: 1432049-32-5
pyridin-2-yl{2-[4-(trifluoromethyl)phenyl]-5,8-dioxaspiro[3.4]oct-2-yl}-methanol

Guidance literature:: Multi-step reaction with 5 steps

1.1: ruthenium(III) trichloride hydrate; sodium periodate / water; dichloromethane; acetonitrile / 0.17 h / 5 - 20 °C

2.1: toluene-4-sulfonic acid / toluene / 2 h / 20 °C / Reflux

3.1: potassium hexamethylsilazane / toluene / 24 h / 60 °C

4.1: n-butyllithium / hexane; diethyl ether / 0.75 h / -70 °C

4.2: 2.5 h / -70 - 20 °C

5.1: methanol; sodium tetrahydroborate / dichloromethane / 2.5 h / 20 °C

With methanol; sodium tetrahydroborate; sodium periodate; n-butyllithium; ruthenium(III) trichloride hydrate; potassium hexamethylsilazane; toluene-4-sulfonic acid; In diethyl ether; hexane; dichloromethane; water; toluene; acetonitrile;