2-fluoro-N-n-propylnorapomorphine

Base Information

• Chemical Name: 2-fluoro-N-n-propylnorapomorphine
• CAS No.: 130434-40-1
• Molecular Formula: BrH*C₁₉H₂₀FNO₂
• Molecular Weight: 394.284
• Mol file: 130434-40-1.mol

Synonyms:2-Fluoro-6-propylnorapomorphinehydrobromide

Chemical Property of 2-fluoro-N-n-propylnorapomorphine

Chemical Property:

• Vapor Pressure: 3.53E-10mmHg at 25°C
• Boiling Point: 488.8°C at 760 mmHg
• Flash Point: 249.4°C
• PSA: 43.70000
• LogP: 4.66520

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-fluoro-N-n-propylnorapomorphine

There total 14 articles about 2-fluoro-N-n-propylnorapomorphine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

2-Fluoro-N-propylnorapocodeine hydrochloride (145568-78-1) → (R)-(-)-2-fluoro-N-n-propylnorapomorphine hydrobromide (130434-40-1)

Guidance literature:

With boron tribromide; In dichloromethane; Ambient temperature;

Reference yield:

(R)-2-fluoro-10,11-(methylenedioxy)-N-n-propylnoraporphine hydrochloride (130434-45-6) → (R)-(-)-2-fluoro-N-n-propylnorapomorphine hydrobromide (130434-40-1)

Guidance literature:

With boron tribromide; In dichloromethane;

DOI:10.1021/jm00174a002

Reference yield:

N-Propyl-O-demethylnormorphothebaine (77630-02-5) → (R)-(-)-2-fluoro-N-n-propylnorapomorphine hydrobromide (130434-40-1)

Guidance literature:

Multi-step reaction with 8 steps

1: NaOH / dimethylsulfoxide

2: NaOH

3: SOCl₂

4: NH₃ / tetrahydrofuran

5: NaH, HMPA

6: 0.17 N aq. HCl

7: NaNO₂, 60percent HPF₆

8: boron tribromide / CH₂Cl₂

With hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydroxide; hexafluorophosphoric acid; thionyl chloride; ammonia; boron tribromide; sodium hydride; sodium nitrite; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;

DOI:10.1021/jm00174a002

upstream raw materials:

(R)-2-fluoro-10,11-(methylenedioxy)-N-n-propylnoraporphine hydrochloride

2-Fluoro-N-propylnorapocodeine hydrochloride

6β-Fluoro-14-hydroxy-6-deoxycodeine

6-Fluoro-6-demethoxythebaine