(2R,6R/S)-(+)-(6-methoxy-4-p-methoxybenzyl-3-oxomorpholin-2-yl)-(R)-hydroxyacetic acid methyl ester

Base Information

Chemical Name:(2R,6R/S)-(+)-(6-methoxy-4-p-methoxybenzyl-3-oxomorpholin-2-yl)-(R)-hydroxyacetic acid methyl ester
CAS No.:250138-05-7
Molecular Formula:C₁₆H₂₁NO₇
Molecular Weight:339.345
Hs Code.:

Synonyms:(2R,6R/S)-(+)-(6-methoxy-4-p-methoxybenzyl-3-oxomorpholin-2-yl)-(R)-hydroxyacetic acid methyl ester

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Chemical Property of (2R,6R/S)-(+)-(6-methoxy-4-p-methoxybenzyl-3-oxomorpholin-2-yl)-(R)-hydroxyacetic acid methyl ester

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Technology Process of (2R,6R/S)-(+)-(6-methoxy-4-p-methoxybenzyl-3-oxomorpholin-2-yl)-(R)-hydroxyacetic acid methyl ester

There total 1 articles about (2R,6R/S)-(+)-(6-methoxy-4-p-methoxybenzyl-3-oxomorpholin-2-yl)-(R)-hydroxyacetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 54879-77-5
N-(4-methoxybenzyl)aminoacetaldehyde dimethyl acetal

: 250138-05-7
(2R,6R/S)-(+)-(6-methoxy-4-p-methoxybenzyl-3-oxomorpholin-2-yl)-(R)-hydroxyacetic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: CH₂Cl₂ / 1 h / 20 °C

2: thionyl chloride / 2 h / 50 °C

With thionyl chloride; In dichloromethane; 1: Acylation / 2: Cyclization;
DOI:10.1021/jo9904967

Reference yield: 82.0%

: 250138-05-7
(2R,6R/S)-(+)-(6-methoxy-4-p-methoxybenzyl-3-oxomorpholin-2-yl)-(R)-hydroxyacetic acid methyl ester

: 250137-80-5
methyl (1R,5S,7R)-3-(p-methoxybenzyl)-2-oxo-6,8-dioxa-3-azabicyclo[3.2.1]octane-7-exo-carboxylate

Guidance literature:: With sulfuric acid; In toluene; for 0.25h; Heating;
DOI:10.1021/jo9904967

Reference yield:

: 250138-05-7
(2R,6R/S)-(+)-(6-methoxy-4-p-methoxybenzyl-3-oxomorpholin-2-yl)-(R)-hydroxyacetic acid methyl ester

: (1S,5S,7S)-3-(p-methoxybenzyl)-7-exo-hydroxymethyl-6,8-dioxa-3-azabicyclo[3.2.1]octane

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / H₂SO₄*SiO₂ / toluene / 0.25 h / Heating

2: 97 percent / LiAlH₄ / tetrahydrofuran / 2 h / Heating

With lithium aluminium tetrahydride; sulfuric acid; In tetrahydrofuran; toluene; 1: Cyclization / 2: Reduction;
DOI:10.1021/jo9904967