2-Iodomethyl-2-methyl-3-[(Z)-phenylimino]-succinic acid diethyl ester

Base Information

• Chemical Name: 2-Iodomethyl-2-methyl-3-[(Z)-phenylimino]-succinic acid diethyl ester
• CAS No.: 119529-52-1
• Molecular Formula: C₁₆H₂₀INO₄
• Molecular Weight: 417.244
• Mol file: 119529-52-1.mol

Synonyms:2-Iodomethyl-2-methyl-3-[(Z)-phenylimino]-succinic acid diethyl ester

Chemical Property of 2-Iodomethyl-2-methyl-3-[(Z)-phenylimino]-succinic acid diethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Iodomethyl-2-methyl-3-[(Z)-phenylimino]-succinic acid diethyl ester

There total 3 articles about 2-Iodomethyl-2-methyl-3-[(Z)-phenylimino]-succinic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

diiodomethane (75-11-6) + (Z)-2-Methyl-3-phenylamino-but-2-enedioic acid diethyl ester (59916-78-8) → 2-Iodomethyl-2-methyl-3-[(Z)-phenylimino]-succinic acid diethyl ester (119529-52-1)

Guidance literature:

With potassium tert-butylate; 18-crown-6 ether; In benzene; for 24h; Ambient temperature;

DOI:10.1021/ja00188a061

Reference yield:

diethyl oxalpropionate (759-65-9) → 2-Iodomethyl-2-methyl-3-[(Z)-phenylimino]-succinic acid diethyl ester (119529-52-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / p-toluenesulfonic acid / benzene / 48 h / Heating

2: 77 percent / t-BuOK / 18-crown-6 / benzene / 24 h / Ambient temperature

With potassium tert-butylate; toluene-4-sulfonic acid; 18-crown-6 ether; In benzene;

DOI:10.1021/ja00188a061

Reference yield:

aniline (62-53-3) → 2-Iodomethyl-2-methyl-3-[(Z)-phenylimino]-succinic acid diethyl ester (119529-52-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / p-toluenesulfonic acid / benzene / 48 h / Heating

2: 77 percent / t-BuOK / 18-crown-6 / benzene / 24 h / Ambient temperature

With potassium tert-butylate; toluene-4-sulfonic acid; 18-crown-6 ether; In benzene;

DOI:10.1021/ja00188a061

upstream raw materials:

diiodomethane

(Z)-2-Methyl-3-phenylamino-but-2-enedioic acid diethyl ester

diethyl oxalpropionate

aniline

Downstream raw materials:

2-Methyl-4-[(Z)-phenylimino]-pentanedioic acid diethyl ester

C₁₆H₂₀⁽²⁾HNO₄