ethyl 4-methyl-8-(p-toluenesulfonyloxy)octanoate

Base Information

Chemical Name:ethyl 4-methyl-8-(p-toluenesulfonyloxy)octanoate
CAS No.:170798-95-5
Molecular Formula:C₁₈H₂₈O₅S
Molecular Weight:356.483
Hs Code.:

Synonyms:ethyl 4-methyl-8-(p-toluenesulfonyloxy)octanoate

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Chemical Property of ethyl 4-methyl-8-(p-toluenesulfonyloxy)octanoate

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Technology Process of ethyl 4-methyl-8-(p-toluenesulfonyloxy)octanoate

There total 5 articles about ethyl 4-methyl-8-(p-toluenesulfonyloxy)octanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 98-59-9
p-toluenesulfonyl chloride

: 170798-80-8
ethyl 8-hydroxy-4-methyloctanoate

: 170798-95-5
ethyl 4-methyl-8-(p-toluenesulfonyloxy)octanoate

Guidance literature:: With pyridine; In dichloromethane; for 12h; Ambient temperature;
DOI:10.1248/cpb.43.607

Reference yield:

: 502-44-3,24980-41-4,80137-66-2
hexahydro-2H-oxepin-2-one

: 170798-95-5
ethyl 4-methyl-8-(p-toluenesulfonyloxy)octanoate

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) LDA, 2.) HMPA

2: diisobutylaluminium hydride / toluene / 4 h / -78 °C

3: 1.) NaH / 1.) C₆H₆, RT, 30 min, 2.) C₆H₆, CH₃C₆H₅, RT, overnight

4: 78 percent / H₂ / 5percent Pd/C / methanol / 5 h / 760 Torr / Ambient temperature

5: 92 percent / pyridine / CH₂Cl₂ / 12 h / Ambient temperature

With pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; hydrogen; sodium hydride; diisobutylaluminium hydride; lithium diisopropyl amide; palladium on activated charcoal; In methanol; dichloromethane; toluene;
DOI:10.1248/cpb.43.607

Reference yield:

: 2549-61-3
3-methylcaprolactone

: 170798-95-5
ethyl 4-methyl-8-(p-toluenesulfonyloxy)octanoate

Guidance literature:: Multi-step reaction with 4 steps

1: diisobutylaluminium hydride / toluene / 4 h / -78 °C

2: 1.) NaH / 1.) C₆H₆, RT, 30 min, 2.) C₆H₆, CH₃C₆H₅, RT, overnight

3: 78 percent / H₂ / 5percent Pd/C / methanol / 5 h / 760 Torr / Ambient temperature

4: 92 percent / pyridine / CH₂Cl₂ / 12 h / Ambient temperature

With pyridine; hydrogen; sodium hydride; diisobutylaluminium hydride; palladium on activated charcoal; In methanol; dichloromethane; toluene;
DOI:10.1248/cpb.43.607