5-{3-[2-(4-bromophenyl)-3-methylbutan-2-yl]-1,2,4-oxadiazol-5-yl}pyrimidine

Base Information

Chemical Name:5-{3-[2-(4-bromophenyl)-3-methylbutan-2-yl]-1,2,4-oxadiazol-5-yl}pyrimidine
CAS No.:1360552-13-1
Molecular Formula:C₁₇H₁₇BrN₄O
Molecular Weight:373.252
Hs Code.:

Synonyms:5-{3-[2-(4-bromophenyl)-3-methylbutan-2-yl]-1,2,4-oxadiazol-5-yl}pyrimidine

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Chemical Property of 5-{3-[2-(4-bromophenyl)-3-methylbutan-2-yl]-1,2,4-oxadiazol-5-yl}pyrimidine

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Technology Process of 5-{3-[2-(4-bromophenyl)-3-methylbutan-2-yl]-1,2,4-oxadiazol-5-yl}pyrimidine

There total 4 articles about 5-{3-[2-(4-bromophenyl)-3-methylbutan-2-yl]-1,2,4-oxadiazol-5-yl}pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1360551-93-4
2-(4-bromo-phenyl)-N-hydroxy-2,3-dimethylbutyramidine

: 4595-61-3
pyrimidine-5-carboxylic acid

: 1360552-13-1
5-{3-[2-(4-bromophenyl)-3-methylbutan-2-yl]-1,2,4-oxadiazol-5-yl}pyrimidine

Guidance literature:: pyrimidine-5-carboxylic acid; With pyridine; thionyl chloride; at 20 ℃; for 0.25h;

2-(4-bromo-phenyl)-N-hydroxy-2,3-dimethylbutyramidine; at 110 ℃; for 18h;

Reference yield:

: 51632-12-3
2-(4-bromophenyl)-3-methylbutyronitrile

: 1360552-13-1
5-{3-[2-(4-bromophenyl)-3-methylbutan-2-yl]-1,2,4-oxadiazol-5-yl}pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C

1.2: 2 h / 0 - 20 °C

2.1: water; hydroxylamine / ethanol / 80 °C

3.1: pyridine; thionyl chloride / 0.25 h / 20 °C

3.2: 18 h / 110 °C

With pyridine; thionyl chloride; water; hydroxylamine; sodium hydride; In ethanol; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 16532-79-9
4-Bromophenylacetonitrile

: 1360552-13-1
5-{3-[2-(4-bromophenyl)-3-methylbutan-2-yl]-1,2,4-oxadiazol-5-yl}pyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C

1.2: 2 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C

2.2: 2 h / 0 - 20 °C

3.1: water; hydroxylamine / ethanol / 80 °C

4.1: pyridine; thionyl chloride / 0.25 h / 20 °C

4.2: 18 h / 110 °C

With pyridine; thionyl chloride; water; hydroxylamine; sodium hydride; In ethanol; N,N-dimethyl-formamide; mineral oil;